Il1rap - interleukin 1 receptor accessory protein Gene

Mus musculus

Also known as IL-1RAcP; 6430709H04Rik

Gene ID: 16180 | Gene type: protein coding

About Il1rap

Summary

Enables interleukin-1 receptor activity; interleukin-33 receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Acts upstream of or within cytokine-mediated signaling pathway; positive regulation of dendrite development; and positive regulation of synapse assembly. Located in glutamatergic synapse. Is expressed in dorsal aorta; future brain; genitourinary system; liver; and ventral grey horn. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2022]

Il1rap Products(4)

mRNA	Protein	Name
NM_001159317.1	NP_001152789.1	interleukin-1 receptor accessory protein isoform c precursor
NM_001159318.1	NP_001152790.1	interleukin-1 receptor accessory protein isoform d precursor
NM_008364.2	NP_032390.1	interleukin-1 receptor accessory protein isoform a precursor
NM_134103.2	NP_598864.1	interleukin-1 receptor accessory protein isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-1 receptor activity	IDA IDA: Inferred from direct assay	11880380	MGI
enables interleukin-33 receptor activity	IMP IMP: Inferred from mutant phenotype	17675517	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10854325	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	11880380	MGI
acts upstream of or within interleukin-2 production	IDA IDA: Inferred from direct assay	11880380	MGI
involved in interleukin-33-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17675517	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	18003919	MGI
involved in positive regulation of interleukin-13 production	IMP IMP: Inferred from mutant phenotype	17675517	MGI
involved in positive regulation of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	17675517	MGI
involved in positive regulation of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	17675517	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18003919	MGI
involved in positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	25908590	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	22357843	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	22357843	MGI
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	22357843	MGI
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	22357843	MGI
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	22357843	MGI
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	22357843	MGI
involved in trans-synaptic signaling by trans-synaptic complex	IDA IDA: Inferred from direct assay	22357843	MGI
involved in trans-synaptic signaling by trans-synaptic complex	IMP IMP: Inferred from mutant phenotype	22357843	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22357843	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22357843	MGI
is active in synapse	IDA IDA: Inferred from direct assay	22357843	MGI
is active in synapse	IMP IMP: Inferred from mutant phenotype	22357843	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-1 receptor accessory protein

IL-1 receptor accessory protein

interleukin-33 receptot beta chain

Il1rap Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Il1rap	Q61730	Il1rl1	Mus musculus	P14719	Anti Tag CoIP	18003919
Intra	Il1rap	Q61730	Tollip	Mus musculus	Q9QZ06	CoIP	10854325
Intra	Il1rap	Q61730	Tollip	Mus musculus	Q9QZ06	Y2H	10854325

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Il1rap Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77417	IL-1RAcP/IL-1 R3 Protein, Mouse (HEK293, Fc)	Q61730-1 (S21-K350)	≥95%
HY-P78311	IL-1RAcP/IL-1 R3 Protein, Mouse (HEK293, His)	Q61730-1 (S21-T367)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99379	Nidanilimab (Nadunolimab)	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06722	IL1RAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il1rap	NCBI	NCBI:3556
Macaca fascicularis	Il1rap	NCBI	NCBI:102133222

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