BRINP1 - BMP/retinoic acid inducible neural specific 1 Gene

Homo sapiens

Also known as DBC1; FAM5A; DBCCR1

Gene ID: 1620 | Gene type: protein coding

About BRINP1

Cytogenetic location: 9q33.1 Genomic coordinates (GRCh38): 9:119,166,629-119,369,435 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 2 paralogues. Biased expression in brain (RPKM 23.7) and adrenal (RPKM 2.3).

Summary

This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq, Jul 2008]

BRINP1 Products(1)

mRNA	Protein	Name
NM_014618.3	NP_055433.2	BMP/retinoic acid-inducible neural-specific protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12442002	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	11420708	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11420708	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRINP1 Protein Structure

MACPF

0
200
400
600
761 a.a.

Protein Preferred Names

Protein Names

BMP/retinoic acid-inducible neural-specific protein 1

bA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A))

BRINP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BRINP1	O60477	ZNF326	Homo sapiens	Q5BKZ1	GMS	22446626

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Transitional Cell Carcinoma

Transitional Cell Neoplasm	Carcinoma, Transitional Cell
Transitional Carcinoma	Transitional Cell Tumor
Urothelial Cell Carcinoma	Carcinoma Transitional Cell
Transitional Cell Carcinoma Of Bladder

Gallbladder Sarcoma

Malignant Mesenchymal Tumor Of Gallbladder

Papillary Transitional Carcinoma

Papillary Transitional Cell Carcinoma

Non-Invasive Bladder Papillary Urothelial Neoplasm

Bladder Papillary Neoplasm Of Low Malignant Potential	Bladder Punlmp
Papillary Urothelial Neoplasm Of Low Malignant Potential	Papillary Transitional Cell Neoplasm Of Low Malignant Potential

Bladder Papillary Transitional Cell Neoplasm

Urinary Bladder Papillary Urothelial Neoplasm

Bladder Papillary Urothelial Neoplasm

Urinary Tract Papillary Transitional Cell Benign Neoplasm

Inverted Papilloma Of Urinary Tract	Papillary Transitional Cell Neoplasm Of The Urinary Tract
Urinary Tract Inverted Papilloma	Inverted Urothelial Papilloma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01620	BRINP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BRINP1	RGD	RGD:708519
Macaca mulatta	BRINP1	VGNC	VGNC:104880
Felis catus	BRINP1	VGNC	VGNC:102903
Canis familiaris	BRINP1	VGNC	VGNC:38527
Mus musculus	BRINP1	MGD	MGI:1928478
Bos taurus	BRINP1	VGNC	VGNC:26567

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