ZNF326 - zinc finger protein 326 Gene

Homo sapiens

Also known as ZIRD; ZAN75; Zfp326; dJ871E2.1

Gene ID: 284695 | Gene type: protein coding

About ZNF326

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,995,110-90,035,533 (from NCBI)

This gene has 4 transcripts (splice variants), 147 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 6.2), endometrium (RPKM 3.4) and 25 other tissues.

Summary

Enables RNA polymerase II complex binding activity. Involved in regulation of DNA-templated transcription, elongation and regulation of RNA splicing. Located in nucleoplasm. Part of DBIRD complex. [provided by Alliance of Genome Resources, Apr 2022]

ZNF326 Products(4)

mRNA	Protein	Name
NM_001320185.2	NP_001307114.1	DBIRD complex subunit ZNF326 isoform 4
NM_181781.4	NP_861446.2	DBIRD complex subunit ZNF326 isoform 2
NM_182975.4	NP_892020.1	DBIRD complex subunit ZNF326 isoform 3
NM_182976.4	NP_892021.1	DBIRD complex subunit ZNF326 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	22446626	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22446626	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of DNA-templated transcription elongation	IMP IMP: Inferred from mutant phenotype	22446626	GOA
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	22446626	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DBIRD complex	IDA IDA: Inferred from direct assay	22446626	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF326 Protein Structure

AKAP95

0
100
200
300
400
500
582 a.a.

Protein Preferred Names

Protein Names

DBIRD complex subunit ZNF326

ZNF-protein interacting with nuclear mRNPs and DBC1

ZNF326 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF326	Q5BKZ1	VMAC	Homo sapiens	Q2NL98	Y2H Array	32296183
Intra	ZNF326	Q5BKZ1	VMAC	Homo sapiens	Q2NL98	Y2H Prey Pooling	32296183
Intra	ZNF326	Q5BKZ1	GEMIN4	Homo sapiens	P57678	Y2H Prey Pooling	32296183
Intra	ZNF326	Q5BKZ1	GEMIN4	Homo sapiens	P57678	Y2H Array	32296183
Intra	ZNF326	Q5BKZ1	SPTA1	Homo sapiens	P02549	Y2H Array	32296183
Intra	ZNF326	Q5BKZ1	SPTA1	Homo sapiens	P02549	Y2H Prey Pooling	32296183
Intra	ZNF326	Q5BKZ1	BRINP1	Homo sapiens	O60477	Anti Bait CoIP	22446626
Intra	ZNF326	Q5BKZ1	BRINP1	Homo sapiens	O60477	Anti Tag CoIP	22446626
Intra	ZNF326	Q5BKZ1	BRINP1	Homo sapiens	O60477	GMS	22446626
Intra	ZNF326	Q5BKZ1	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
Intra	ZNF326	Q5BKZ1	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
Intra	ZNF326	Q5BKZ1	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	ZNF326	Q5BKZ1	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lenz-Majewski Hyperostotic Dwarfism

Lenz-Majewski Syndrome	Lenz Majewski Hyperostotic Dwarfism
LMHD	Hyperostotic Dwarfism Lenz-Majewski Type
Lenz-Majewski Hyperostotic Dysplasia	Multiple Congenital Anomalies, Intellectual Disability And Progressive Skeletal Sclerosis
Lms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16125	ZNF326 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZNF326	VGNC	VGNC:67290
Canis familiaris	ZNF326	VGNC	VGNC:48699
Bos taurus	ZNF326	VGNC	VGNC:37248
Rattus norvegicus	ZNF326	RGD	RGD:1592829
Macaca mulatta	ZNF326	VGNC	VGNC:78945
Mus musculus	ZNF326	MGD	MGI:1927246

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