DBP - D-box binding PAR bZIP transcription factor Gene

Homo sapiens

Also known as DABP; taxREB302

Gene ID: 1628 | Gene type: protein coding

About DBP

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,630,030-48,637,379 (from NCBI)

This gene has 5 transcripts (splice variants), 251 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 6.3), spleen (RPKM 6.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

DBP Products(1)

mRNA	Protein	Name
NM_001352.5	NP_001343.2	D site-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20093779	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20093779	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20093779	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DBP Protein Structure

bZIP_2

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

D site-binding protein

D site of albumin promoter (albumin D-box) binding protein

DBP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DBP	Q10586	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	DBP	Q10586	HLF	Homo sapiens	Q16534	FRET	23661758
Intra	DBP	Q10586	DDIT3	Homo sapiens	P35638	Y2H	21988832
Intra	DBP	Q10586	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	DBP	Q10586	BATF	Homo sapiens	Q16520	FRET	23661758

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hemophilia B

Christmas Disease	Factor Ix Deficiency
F9 Deficiency	HEMB
Plasma Thromboplastin Component Deficiency	Congenital Factor Ix Deficiency
Mild Hemophilia B	Severe Hemophilia B
Congenital Factor Ix Disorder	Deficiency, Functional Factor Ix
Hem B	Mild Congenital F9 Deficiency
Mild Congenital Factor Ix Deficiency	Moderate Hemophilia B
Moderate Congenital F9 Deficiency	Moderate Congenital Factor Ix Deficiency
Severe Congenital F9 Deficiency	Severe Congenital Factor Ix Deficiency
Bleeding Disorder In Hemophilia B Carriers	Congenital F9 Deficiency
Recessive X-Linked Hemophilia B

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N7143	Monobutyl phthalate		99.85%	Unkown
HY-133630	1-Bromo-1,1-dichloroacetone		/	Unkown
HY-133631	Chloronitromethane		≥98.0%	Unkown
HY-133625	1,1-Dibromo-3-chloroacetone		/	Unkown
HY-133626	1,1-Dibromo-3,3-dichloroacetone		/	Unkown
HY-133627	1,3-Dibromo-1,3-dichloroacetone		/	Unkown
HY-133628	1,1,3-Tribromo-3-chloroacetone		/	Unkown
HY-133633	Bromodichloronitromethane		/	Unkown
HY-133635	Tribromonitromethane		/	Unkown
HY-133636	Bromochloronitromethane		/	Unkown
HY-133656	(Z)-2-Bromo-3-methyl-2-butenedioic acid		/	Unkown
HY-133657	Bromoiodoacetic acid		/	Unkown
HY-133659	Diiodoacetic acid		/	Unkown
HY-133664	Dibromochloroacetamide		/	Unkown
HY-133665	2,2-Dibromoacetamide		/	Unkown
HY-133666	Diiodoacetamide		/	Unkown
HY-RS03552	DBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-133629	1,1,1,3-Tetrachloroacetone		/	Unkown
HY-133634	Dibromochloronitromethane		/	Unkown
HY-133655	(E)-2,3-Dibromo-2-butenedioic acid		/	Unkown
HY-W243879	Tetraphenyldibenzoperiflanthene		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DBP	VGNC	VGNC:39785
Macaca mulatta	DBP	VGNC	VGNC:71743
Bos taurus	DBP	VGNC	VGNC:27894
Rattus norvegicus	DBP	RGD	RGD:2491
Mus musculus	DBP	MGD	MGI:94866
Others	DBP	NCBI

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