BATF - basic leucine zipper ATF-like transcription factor Gene

Homo sapiens

Also known as SFA2; B-ATF; BATF1; SFA-2

Gene ID: 10538 | Gene type: protein coding

About BATF

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:75,522,469-75,546,992 (from NCBI)

This gene has 3 transcripts (splice variants), 203 orthologues and 8 paralogues. Broad expression in lymph node (RPKM 11.0), appendix (RPKM 9.8) and 14 other tissues.

Summary

The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008]

BATF Products(1)

mRNA	Protein	Name
NM_006399.5	NP_006390.1	basic leucine zipper transcriptional factor ATF-like

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8954125	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BATF Protein Structure

bZIP_1

0
100
125 a.a.

Protein Preferred Names

Protein Names

basic leucine zipper transcriptional factor ATF-like

B-cell-activating transcription factor

Related Diseases

Diseases

Alias

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01372	BATF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01371	BATF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01373	BATF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BATF	VGNC	VGNC:70229
Rattus norvegicus	BATF	RGD	RGD:1304923
Bos taurus	BATF	VGNC	VGNC:26425
Felis catus	BATF	VGNC	VGNC:81030
Canis familiaris	BATF	VGNC	VGNC:38385
Mus musculus	BATF	MGD	MGI:1859147

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