2. Gene
  3. BATF3 - basic leucine zipper ATF-like transcription factor 3 Gene

BATF3 - basic leucine zipper ATF-like transcription factor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as JDP1; SNFT; JUNDM1

Gene ID: 55509 | Gene type: protein coding

About BATF3

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,686,417-212,699,840 (from NCBI)

This gene has 3 transcripts (splice variants), 173 orthologues and 8 paralogues. Broad expression in spleen (RPKM 2.9), appendix (RPKM 1.9) and 20 other tissues.

Summary

This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]

BATF3 Products(1)

mRNA Protein Name
NM_018664.3 NP_061134.1 basic leucine zipper transcriptional factor ATF-like 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15467742 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15467742 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20102225 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15467742 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
20102225 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BATF3 Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (33 - 93)

  • 0
  • 100
  • 127 a.a.
Protein Preferred Names Protein Names

basic leucine zipper transcriptional factor ATF-like 3

21 kDa small nuclear factor isolated from T-cells

BATF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638-2
Y2H Array
25416956
Intra BATF3 Q9NR55 CREB5 Homo sapiens Q02930-3
Y2H Prey Pooling
32296183
Intra BATF3 Q9NR55 CREB5 Homo sapiens Q02930-3
Y2H Array
32296183
Intra BATF3 Q9NR55 ATF2 Homo sapiens P15336
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 ATF2 Homo sapiens P15336
Anti Tag CoIP
28514442
Intra BATF3 Q9NR55 ATF2 Homo sapiens P15336
FRET
23661758
Intra BATF3 Q9NR55 GPATCH2L Homo sapiens Q9NWQ4-1
Validated Y2H
32296183
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
FRET
23661758
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra BATF3 Q9NR55 BACH2 Homo sapiens Q9BYV9
Anti Tag CoIP
28514442
Intra BATF3 Q9NR55 JUND Homo sapiens P17535
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 JUND Homo sapiens P17535
Anti Tag CoIP
28514442
Intra BATF3 Q9NR55 JUND Homo sapiens P17535
Peptide Array
20102225
Intra BATF3 Q9NR55 DBP Homo sapiens Q10586
FRET
23661758
Intra BATF3 Q9NR55 ATF4 Homo sapiens P18848
FRET
23661758
Intra BATF3 Q9NR55 ATF3 Homo sapiens P18847
Peptide Array
20102225
Intra BATF3 Q9NR55 ATF3 Homo sapiens P18847
FRET
23661758
Intra BATF3 Q9NR55 MAFG Homo sapiens O15525
FRET
23661758
Intra BATF3 Q9NR55 MAFF Homo sapiens Q9ULX9
FRET
23661758
Intra BATF3 Q9NR55 CEBPG Homo sapiens P53567
FRET
23661758
Intra BATF3 Q9NR55 CEBPG Homo sapiens P53567
Peptide Array
20102225
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638
FRET
23661758
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638
Y2H Array
32296183
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638
Peptide Array
20102225
Intra BATF3 Q9NR55 DDIT3 Homo sapiens P35638
Y2H Prey Pooling
32296183
Intra BATF3 Q9NR55 FOSL1 Homo sapiens P15407
Y2H Array
32296183
Intra BATF3 Q9NR55 FOSL1 Homo sapiens P15407
Y2H Prey Pooling
32296183
Intra BATF3 Q9NR55 JUNB Homo sapiens P17275
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 JUNB Homo sapiens P17275
Anti Tag CoIP
28514442
Intra BATF3 Q9NR55 JUNB Homo sapiens P17275
Peptide Array
20102225
Intra BATF3 Q9NR55 JUN Homo sapiens P05412
Peptide Array
20102225
Intra BATF3 Q9NR55 JUN Homo sapiens P05412
FRET
23661758
Intra BATF3 Q9NR55 JUN Homo sapiens P05412
Anti Tag CoIP
33961781
Intra BATF3 Q9NR55 JUN Homo sapiens P05412
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dendritic Cell Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01373 BATF3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris BATF3 VGNC VGNC:38387
Bos taurus BATF3 VGNC VGNC:26427
Mus musculus BATF3 MGD MGI:1925491
Felis catus BATF3 VGNC VGNC:107843
Macaca mulatta BATF3 VGNC VGNC:70143
Rattus norvegicus BATF3 RGD RGD:620501