DFFA - DNA fragmentation factor subunit alpha Gene

Homo sapiens

Also known as DFF1; ICAD; DFF-45

Gene ID: 1676 | Gene type: protein coding

About DFFA

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:10,456,522-10,472,529 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 6.3), kidney (RPKM 5.8) and 25 other tissues.

Summary

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for Caspase-3 and triggers DNA fragmentation during Apoptosis. DFF becomes activated when DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during Apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DFFA Products(2)

mRNA	Protein	Name
NM_004401.3	NP_004392.1	DNA fragmentation factor subunit alpha isoform 1
NM_213566.2	NP_998731.1	DNA fragmentation factor subunit alpha isoform 2

DFFA Protein Structure

CIDE-N

DFF-C

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

DNA fragmentation factor subunit alpha

DFF45

Recombinant DFFA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7814	DFF45/ICAD Protein, Human (His)	AAH07721.1 (M1-T331)	≥95%
HY-P700499	DFFA Protein, Human (GST)	O00273 (M1-T331)	≥95%

Related Diseases

Diseases

Alias

Basilar Artery Occlusion

Vertebral Artery Occlusion

Occlusion And Stenosis Of Vertebral Artery

Vertebrobasilar Insufficiency

Vertebro-Basilar Insufficiency	Vertebrobasilar Arterial Insufficiency
Vertebrobasilar Artery Syndrome

Horner'S Syndrome

Horner Syndrome	Bernard-Horner Syndrome
Oculosympathetic Palsy	Bernard Horner Syndrome
Cervical Sympathetic Paralysis	Von Passow Syndrome
Cervical Sympathetic Dystrophy

Vertebral Artery Insufficiency

Vertebral Artery Syndrome

Chronic Dacryocystitis

Moyamoya Disease 1

Moyamoya Disease	Spontaneous Occlusion Of The Circle Of Willis
Mymy	Progressive Intracranial Arterial Occlusion
Moyamoya Syndrome	MYMY1
Cerebrovascular Moyamoya Disease	Moya-Moya Disease
Progressive Intracranial Occlusive Arteropathy	Idiopathic Moyamoya Disease

Occlusion Precerebral Artery

Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries

Occlusion And Stenosis Of Precerebral Artery

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03708	DFFA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DFFA	MGD	MGI:1196227
Rattus norvegicus	DFFA	RGD	RGD:620334
Macaca mulatta	DFFA	VGNC	VGNC:71771
Others	DFFA	NCBI

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