Lbp - lipopolysaccharide binding protein Gene

Mus musculus

Also known as Ly88; Bpifd2

Gene ID: 16803 | Gene type: protein coding

About Lbp

Summary

Enables lipopolysaccharide binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of respiratory burst involved in inflammatory response; positive regulation of tumor necrosis factor production; and response to bacterium. Acts upstream of or within several processes, including defense response to Gram-negative bacterium; leukocyte chemotaxis involved in inflammatory response; and positive regulation of neutrophil chemotaxis. Located in cell surface and extracellular space. Is expressed in brain; heart ventricle; liver lobe; and reproductive system. Orthologous to human LBP (lipopolysaccharide binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Lbp Products(1)

mRNA	Protein	Name
NM_008489.2	NP_032515.2	lipopolysaccharide-binding protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	11079463	MGI
enables signaling receptor binding	IDA IDA: Inferred from direct assay	9338787	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute-phase response	IMP IMP: Inferred from mutant phenotype	12932360	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	24380872	MGI
acts upstream of or within defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	12055258	MGI
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	9338787	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	12932360	MGI
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	12932360	MGI
acts upstream of or within leukocyte chemotaxis involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	12055258	MGI
involved in macrophage activation involved in immune response	IDA IDA: Inferred from direct assay	12932360	MGI
acts upstream of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	12055258	MGI
acts upstream of or within positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	12055258	MGI
acts upstream of or within positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	12055258	MGI
involved in positive regulation of respiratory burst involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	9338787	MGI
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12932360	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	12055258	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	9338787	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	12055258	MGI
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	9338787	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	12055258	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	12932360	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	9338787	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lipopolysaccharide-binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141882	DC-LC3in-D5	Inhibitor	98.62%	Unkown
HY-106010	LBP1	Agonist	/	Unkown
HY-155437	NEt-iFQ	Agonist	/	Unkown
HY-RS07543	LBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07544	Lbp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lbp	NCBI	NCBI:3929
Macaca fascicularis	Lbp	NCBI	NCBI:102124806
Rattus norvegicus	Lbp	NCBI	NCBI:29469
Macaca mulatta	Lbp	NCBI	NCBI:706109

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