2. Gene
  3. Lbp - lipopolysaccharide binding protein Gene

Lbp - lipopolysaccharide binding protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bpifd2

Gene ID: 29469 | Gene type: protein coding

About Lbp

Primary_assembly 3: 146,954,015-146,981,586 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 104 orthologues, 12 paralogues and is associated with 18 phenotypes. Biased expression in Liver (RPKM 34.4), Heart (RPKM 58.6) and 5 other tissues.

Summary

Enables lipopolysaccharide binding activity. Involved in several processes, including liver development; positive regulation of macrophage activation; and positive regulation of phagocytosis, engulfment. Located in extracellular space. Used to study obesity. Biomarker of liver cirrhosis; obstructive jaundice; and periodontitis. Orthologous to human LBP (lipopolysaccharide binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Lbp Products(1)

mRNA Protein Name
NM_017208.2 NP_058904.2 lipopolysaccharide-binding protein precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
22580761 RGD
Biological Process GO Annotation Evidence Reference Source
involved in liver development IEP
IEP: Inferred from expression pattern
20978830 RGD
involved in positive regulation of macrophage activation IDA
IDA: Inferred from direct assay
10733550 RGD
involved in positive regulation of phagocytosis, engulfment IDA
IDA: Inferred from direct assay
11104656 RGD
involved in regulation of membrane permeability IMP
IMP: Inferred from mutant phenotype
17446308 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
23277536 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
22580761 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lbp Protein Structure

BPI1

BPI1: cd00025 (30 - 251)

LBP_BPI_CETP_C

LBP_BPI_CETP_C: pfam02886 (240 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

lipopolysaccharide-binding protein

BPI fold containing family D, member 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141882 DC-LC3in-D5 Inhibitor 98.51% Unkown
HY-106010 LBP1 Agonist / Unkown
HY-155437 NEt-iFQ Agonist / Unkown
HY-RS07543 LBP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07544 Lbp Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lbp NCBI NCBI:3929
Macaca fascicularis Lbp NCBI NCBI:102124806
Mus musculus Lbp NCBI NCBI:16803
Macaca mulatta Lbp NCBI NCBI:706109