Lpl - lipoprotein lipase Gene

Mus musculus

Gene ID: 16956 | Gene type: protein coding

About Lpl

Summary

Enables lipoprotein Lipase activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of macrophage derived foam cell differentiation; and triglyceride catabolic process. Acts upstream of or within response to bacterium. Located in cell surface and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; limb; lung; and sensory organ. Used to study familial lipoprotein Lipase deficiency. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein Lipase). [provided by Alliance of Genome Resources, Apr 2022]

Lpl Products(1)

mRNA	Protein	Name
NM_008509.2	NP_032535.2	lipoprotein lipase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lipoprotein lipase activity	IDA IDA: Inferred from direct assay	2563260	MGI
enables triacylglycerol lipase activity	IDA IDA: Inferred from direct assay	15178420	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fatty acid	IDA IDA: Inferred from direct assay	21986524	MGI
involved in cellular response to nutrient	IDA IDA: Inferred from direct assay	21986524	MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production	IGI IGI: Inferred from genetic interaction	22963823	MGI
involved in positive regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	22963823	MGI
involved in positive regulation of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	22963823	MGI
involved in positive regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	22963823	MGI
involved in positive regulation of macrophage derived foam cell differentiation	IGI IGI: Inferred from genetic interaction	10858435	MGI
involved in positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	22963823	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
involved in triglyceride catabolic process	IDA IDA: Inferred from direct assay	15178420	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	20620994	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	15178420	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lipoprotein lipase

O 1-4-5

phospholipase A1

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P2752	Lipoprotein lipase, Pseudomonas sp		/	Phase 3
HY-117549	Ibrolipim	Activator	99.30%	Phase 2
HY-119741	Salacinol	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N5015	Rosmanol	Inhibitor	98.70%	Unkown
HY-101395A	W146 TFA		98.13%	Unkown
HY-P4153	Enlicitide chloride	Inhibitor	98.74%	Unkown
HY-128671	6-Thioinosine		98.82%	Unkown
HY-RS07772	LPL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lpl	NCBI	NCBI:4023
Macaca fascicularis	Lpl	NCBI	NCBI:102129758
Rattus norvegicus	Lpl	NCBI	NCBI:24539

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