2. Gene
  3. Lpl - lipoprotein lipase Gene

Lpl - lipoprotein lipase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24539 | Gene type: protein coding

About Lpl

Summary

Enables lipoprotein Lipase activity and triglyceride binding activity. Involved in several processes, including negative regulation of cellular response to Insulin stimulus; response to cold; and triglyceride biosynthetic process. Located in extracellular space. Used to study abdominal obesity-metabolic syndrome 1; familial hyperlipidemia; non-alcoholic fatty liver disease; and obesity. Biomarker of end stage renal disease; focal segmental glomerulosclerosis; non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein Lipase). [provided by Alliance of Genome Resources, Apr 2022]

Lpl Products(1)

mRNA Protein Name
NM_012598.2 NP_036730.1 lipoprotein lipase precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lipoprotein lipase activity IDA
IDA: Inferred from direct assay
11788374 RGD
enables triglyceride binding IDA
IDA: Inferred from direct assay
12551943 RGD
Biological Process GO Annotation Evidence Reference Source
involved in lipid catabolic process IDA
IDA: Inferred from direct assay
12551943 RGD
involved in negative regulation of cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
25931001 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11016888 RGD
involved in triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
11788374 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
12551943 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lipoprotein lipase

phospholipase A1

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P2752 Lipoprotein lipase, Pseudomonas sp / Phase 3
HY-117549 Ibrolipim Activator 99.30% Phase 2
HY-119741 Salacinol Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N5015 Rosmanol Inhibitor 98.70% Unkown
HY-101395A W146 TFA 98.13% Unkown
HY-P4153 Enlicitide chloride Inhibitor 98.74% Unkown
HY-128671 6-​Thioinosine 98.82% Unkown
HY-RS07772 LPL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpl NCBI NCBI:4023
Macaca fascicularis Lpl NCBI NCBI:102129758
Mus musculus Lpl NCBI NCBI:16956