2. Gene
  3. Dkc1 - dyskerin pseudouridine synthase 1 Gene

Dkc1 - dyskerin pseudouridine synthase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Nap57

Gene ID: 170944 | Gene type: protein coding

About Dkc1

Summary

Predicted to enable box H/ACA snoRNA binding activity; pseudouridine synthase activity; and Telomerase RNA binding activity. Predicted to contribute to Telomerase activity. Involved in positive regulation of cell population proliferation and snoRNA guided rRNA pseudouridine synthesis. Located in Cajal body and nucleolus. Part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in X-linked dyskeratosis congenita; aplastic anemia; and dyskeratosis congenita. Orthologous to human DKC1 (dyskerin pseudouridine synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dkc1 Products(1)

mRNA Protein Name
NM_133419.1 NP_596910.1 H/ACA ribonucleoprotein complex subunit DKC1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
7798307 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10679015 RGD
involved in snoRNA guided rRNA pseudouridine synthesis IDA
IDA: Inferred from direct assay
12446766 RGD
Cellular Component GO Annotation Evidence Reference Source
located in Cajal body IDA
IDA: Inferred from direct assay
7798307 RGD
part of box H/ACA snoRNP complex IDA
IDA: Inferred from direct assay
10679015 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
7798307 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H/ACA ribonucleoprotein complex subunit DKC1

dyskeratosis congenita 1, dyskerin

h/ACA ribonucleoprotein complex subunit 4

nopp140-associated protein of 57 kDa

nucleolar protein NAP57

nucleolar protein family A member 4

snoRNP protein DKC1

Dkc1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Dkc1 P40615 NAF1 Homo sapiens Q96HR8
Anti Bait CoIP
16618814
Intra
Dkc1 P40615 Nop10 Rattus norvegicus D3ZMP6
Anti Bait CoIP
16618814
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03786 DKC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dkc1 NCBI NCBI:1736