NAF1 - nuclear assembly factor 1 ribonucleoprotein Gene

Homo sapiens

Gene ID: 92345 | Gene type: protein coding

About NAF1

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,103,929-163,166,890 (from NCBI)

This gene has 6 transcripts (splice variants) and 188 orthologues. Ubiquitous expression in testis (RPKM 1.9), endometrium (RPKM 1.8) and 25 other tissues.

Summary

Enables identical protein binding activity and Telomerase RNA binding activity. Involved in regulation of nucleobase-containing compound metabolic process; ribosome biogenesis; and Telomerase holoenzyme complex assembly. Located in nucleoplasm. Part of sno(s)RNA-containing ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

NAF1 Products(2)

mRNA	Protein	Name
NM_001128931.2	NP_001122403.1	H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform b
NM_138386.3	NP_612395.2	H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	16618814	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16601202	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	27510903	GOA
acts upstream of positive regulation of telomere maintenance via telomere lengthening	IMP IMP: Inferred from mutant phenotype	27510903	GOA
involved in ribosome biogenesis	IDA IDA: Inferred from direct assay	16618814	GOA
involved in telomerase RNA stabilization	IMP IMP: Inferred from mutant phenotype	27510903	GOA
involved in telomerase holoenzyme complex assembly	IMP IMP: Inferred from mutant phenotype	27510903	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	27510903	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	27510903	GOA
part of sno(s)RNA-containing ribonucleoprotein complex	IDA IDA: Inferred from direct assay	16601202	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAF1 Protein Structure

Gar1

0
100
200
300
400
494 a.a.

Protein Preferred Names

Protein Names

H/ACA ribonucleoprotein complex non-core subunit NAF1

nuclear assembly factor 1 homolog

Related Diseases

Diseases

Alias

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09008	NAF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NAF1	MGD	MGI:2682306
Macaca mulatta	NAF1	VGNC	VGNC:75020
Rattus norvegicus	NAF1	RGD	RGD:1306802
Bos taurus	NAF1	VGNC	VGNC:54460
Felis catus	NAF1	VGNC	VGNC:63712

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