Cx3cr1 - C-X3-C motif chemokine receptor 1 Gene

Rattus norvegicus

Also known as Rbs11

Gene ID: 171056 | Gene type: protein coding

About Cx3cr1

Primary_assembly 8: 119,782,595-119,800,014 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 259 orthologues, 24 paralogues and is associated with 61 phenotypes. Biased expression in Brain (RPKM 41.7), Kidney (RPKM 28.8) and 9 other tissues.

Summary

Enables C-X3-C Chemokine Receptor activity. Involved in several processes, including negative regulation of apoptotic process; regulation of cell migration; and regulation of gene expression. Located in several cellular components, including cell surface; neuronal cell body membrane; and perinuclear region of cytoplasm. Used to study Parkinsonism; glomerulonephritis; hepatopulmonary syndrome; and status epilepticus. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); borna disease; portal hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cx3cr1 Products(1)

mRNA	Protein	Name
NM_133534.2	NP_598218.1	CX3C chemokine receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C-X3-C chemokine receptor activity	IDA IDA: Inferred from direct assay	11278650	RGD
enables chemokine receptor activity	IMP IMP: Inferred from mutant phenotype	10415068	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12729461	RGD
involved in autocrine signaling	IGI IGI: Inferred from genetic interaction	12729461	RGD
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	10415068	RGD
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	12729461	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	10422773	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	12446007	RGD
involved in cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	12729461	RGD
involved in chemokine-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	10869418	RGD
involved in chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10415068	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	23855980	RGD
involved in negative regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	10869418	RGD
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17114429	RGD
involved in negative regulation of hippocampal neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10869418	RGD
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	20018408	RGD
involved in negative regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	23855980	RGD
involved in positive regulation of I-kappaB phosphorylation	IGI IGI: Inferred from genetic interaction	10869418	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18006432	RGD
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	10869418	RGD
involved in positive regulation of microglial cell migration	IMP IMP: Inferred from mutant phenotype	10415068	RGD
involved in positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	20018408	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	10869418	RGD
involved in response to ischemia	IGI IGI: Inferred from genetic interaction	12059974	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	10415068	RGD
located in dendritic tree	IDA IDA: Inferred from direct assay	10869418	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	10869418	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11870871	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cx3cr1 Protein Structure

7tmA_CX3CR1

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

CX3C chemokine receptor 1

C-X3-C CKR-1	chemokine (C-X3-C motif) receptor 1
chemokine (C-X3-C) receptor 1	fractalkine receptor

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928	Alirocumab		97.00%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13848	AZD8797		99.54%	Phase 2
HY-107456	E6130		≥98.0%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9928A	Alirocumab (anti-PCSK9)		98.24%	Phase 4

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123918	JMS-17-2		99.59%	Unkown
HY-168975	Fosrugocrixan	Antagonist	/	Unkown
HY-123918A	JMS-17-2 hydrochloride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cx3cr1	NCBI	NCBI:1524

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