2. Gene
  3. Mdm2 - transformed mouse 3T3 cell double minute 2 Gene

Mdm2 - transformed mouse 3T3 cell double minute 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mdm-2; 1700007J15Rik

Gene ID: 17246 | Gene type: protein coding

About Mdm2

Chromosome 10: 117,524,780-117,546,663 reverse strand.GRCm39:CM001003.3

This gene has 9 transcripts (splice variants), 247 orthologues, 1 paralogue and is associated with 56 phenotypes. Ubiquitous expression in testis adult (RPKM 1.8), CNS E11.5 (RPKM 9.8) and 28 other tissues.

Summary

Enables p53 binding activity and ubiquitin protein Ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland Cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Mdm2 Products(2)

mRNA Protein Name
NM_010786.4 NP_034916.1 E3 ubiquitin-protein ligase Mdm2 isoform 1
NM_001288586.2 NP_001275515.1 E3 ubiquitin-protein ligase Mdm2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables p53 binding IPI
IPI: Inferred from physical interaction
15678128 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10906133 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
12145204 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
17591690 MGI
Biological Process GO Annotation Evidence Reference Source
involved in apoptotic process IDA
IDA: Inferred from direct assay
30879903 MGI
acts upstream of or within atrial septum development IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within atrioventricular valve morphogenesis IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
22821713 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
22821713 MGI
acts upstream of or within cardiac septum morphogenesis IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of cell cycle IGI
IGI: Inferred from genetic interaction
15485902 MGI
acts upstream of or within endocardial cushion morphogenesis IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within endocardial cushion morphogenesis IMP
IMP: Inferred from mutant phenotype
22821713 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
22821713 MGI
acts upstream of or within heart valve development IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within positive regulation of cell cycle IGI
IGI: Inferred from genetic interaction
15485902 MGI
involved in positive regulation of muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
25720496 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22821713 MGI
acts upstream of or within regulation of heart rate IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within traversing start control point of mitotic cell cycle IDA
IDA: Inferred from direct assay
10906133 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
12145204 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
25720496 MGI
acts upstream of or within ventricular septum development IGI
IGI: Inferred from genetic interaction
22821713 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14767071 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
11718560 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11718560 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mdm2 Protein Structure

MDM2

MDM2: cd17672 (24 - 106)

zf-RanBP

zf-RanBP: pfam00641 (296 - 325)

mRING-HC-C2H2C4_MDM2

mRING-HC-C2H2C4_MDM2: cd16783 (432 - 487)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 489 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Mdm2

RING-type E3 ubiquitin transferase Mdm2

double minute 2 protein

oncoprotein Mdm2

p53-binding protein Mdm2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128837 Nutlin carboxylic acid 98.63% Unkown
HY-168280 AS1411-C4-VH032 Degrader / Unkown
HY-128836 (4R,5S)-Nutlin carboxylic acid / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mdm2 NCBI NCBI:4193