Mef2c - myocyte enhancer factor 2C Gene

Mus musculus

Also known as Mef2; 5430401D19Rik; 9930028G15Rik

Gene ID: 17260 | Gene type: protein coding

About Mef2c

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and histone deacetylase binding activity. Involved in several processes, including animal organ development; modulation of chemical synaptic transmission; and positive regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; cardiac muscle hypertrophy in response to stress; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 20. Orthologous to human MEF2C (myocyte enhancer factor 2C). [provided by Alliance of Genome Resources, Apr 2022]

Mef2c Products(18)

mRNA	Protein	Name
NM_001170537.2	NP_001164008.1	myocyte-specific enhancer factor 2C isoform 1
NM_001347564.2	NP_001334493.1	myocyte-specific enhancer factor 2C isoform 3
NM_001347566.2	NP_001334495.1	myocyte-specific enhancer factor 2C isoform 3
NM_001347567.2	NP_001334496.1	myocyte-specific enhancer factor 2C isoform 3
NM_001347568.2	NP_001334497.1	myocyte-specific enhancer factor 2C isoform 4
NM_001347569.2	NP_001334498.1	myocyte-specific enhancer factor 2C isoform 4
NM_001347571.2	NP_001334500.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347572.2	NP_001334501.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347573.2	NP_001334502.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347574.2	NP_001334503.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347575.2	NP_001334504.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347576.2	NP_001334505.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347577.2	NP_001334506.1	myocyte-specific enhancer factor 2C isoform 5
NM_001347578.2	NP_001334507.1	myocyte-specific enhancer factor 2C isoform 6
NM_001347579.2	NP_001334508.1	myocyte-specific enhancer factor 2C isoform 7
NM_001347580.2	NP_001334509.1	myocyte-specific enhancer factor 2C isoform 7
NM_001347581.2	NP_001334510.1	myocyte-specific enhancer factor 2C isoform 8
NM_025282.4	NP_079558.1	myocyte-specific enhancer factor 2C isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14762206	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7760790	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	20181743	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12130539	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17420000	MGI
enables HMG box domain binding	IPI IPI: Inferred from physical interaction	11554755	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7760790	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15890826	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18086704	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16140986	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	10983972	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12130539	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17336904	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	8035824	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of negative effect AMPA selective glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18599438	MGI
involved in B cell homeostasis	IMP IMP: Inferred from mutant phenotype	19211936	MGI
involved in B cell proliferation	IMP IMP: Inferred from mutant phenotype	18438409	MGI
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18955699	MGI
involved in MAPK cascade	IDA IDA: Inferred from direct assay	14515274	MGI
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	18955699	MGI
acts upstream of negative effect NMDA selective glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18599438	MGI
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	30735130	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	9778514	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	9162005	MGI
acts upstream of or within cardiac muscle cell differentiation	IGI IGI: Inferred from genetic interaction	19035347	MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	10531040	MGI
acts upstream of or within cardiac ventricle formation	IGI IGI: Inferred from genetic interaction	19035347	MGI
involved in cardiac ventricle formation	IMP IMP: Inferred from mutant phenotype	16680724	MGI
acts upstream of or within cartilage morphogenesis	IMP IMP: Inferred from mutant phenotype	17420000	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	19169261	MGI
involved in cell morphogenesis involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	18599437	MGI
acts upstream of cell proliferation in bone marrow	IGI IGI: Inferred from genetic interaction	18278031	MGI
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	15998798	MGI
involved in cellular response to fluid shear stress	IDA IDA: Inferred from direct assay	20181743	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	18955699	MGI
involved in cellular response to trichostatin A	IDA IDA: Inferred from direct assay	20181743	MGI
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16775627	MGI
acts upstream of or within chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	17336904	MGI
involved in embryonic heart tube development	IGI IGI: Inferred from genetic interaction	30735130	MGI
involved in embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	30735130	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	17420000	MGI
acts upstream of or within embryonic viscerocranium morphogenesis	IMP IMP: Inferred from mutant phenotype	17420000	MGI
acts upstream of or within endochondral ossification	IGI IGI: Inferred from genetic interaction	17336904	MGI
acts upstream of or within endochondral ossification	IMP IMP: Inferred from mutant phenotype	17336904	MGI
involved in epithelial cell proliferation involved in renal tubule morphogenesis	IMP IMP: Inferred from mutant phenotype	20181743	MGI
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	18599437	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	30735130	MGI
involved in germinal center formation	IMP IMP: Inferred from mutant phenotype	18955699	MGI
involved in glomerulus morphogenesis	IMP IMP: Inferred from mutant phenotype	20181743	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	9778514	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	16680724	MGI
involved in humoral immune response	IMP IMP: Inferred from mutant phenotype	18955699	MGI
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	18599437	MGI
involved in melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	21610032	MGI
acts upstream of or within monocyte differentiation	IMP IMP: Inferred from mutant phenotype	18326819	MGI
acts upstream of or within muscle cell fate determination	IMP IMP: Inferred from mutant phenotype	17786239	MGI
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20181743	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16680724	MGI
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	18579729	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7677753	MGI
involved in nephron tubule epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	20181743	MGI
involved in neural crest cell differentiation	IMP IMP: Inferred from mutant phenotype	21610032	MGI
involved in neuron development	IMP IMP: Inferred from mutant phenotype	18599437	MGI
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	18599437	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	18599437	MGI
involved in osteoblast differentiation	IEP IEP: Inferred from expression pattern	21652706	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	17336904	MGI
acts upstream of or within outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	19035347	MGI
involved in platelet formation	IMP IMP: Inferred from mutant phenotype	19211936	MGI
involved in positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	18955699	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9738004	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11554755	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9162005	MGI
involved in positive regulation of alkaline phosphatase activity	IMP IMP: Inferred from mutant phenotype	21652706	MGI
involved in positive regulation of behavioral fear response	IMP IMP: Inferred from mutant phenotype	18579729	MGI
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	21652706	MGI
involved in positive regulation of cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16680724	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16680724	MGI
acts upstream of or within positive regulation of cell proliferation in bone marrow	IGI IGI: Inferred from genetic interaction	18278031	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18579729	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16680724	MGI
involved in positive regulation of macrophage apoptotic process	IMP IMP: Inferred from mutant phenotype	16775627	MGI
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	18579729	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	21652706	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16818234	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7760790	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	8900141	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15890826	MGI
involved in primary heart field specification	IMP IMP: Inferred from mutant phenotype	16680724	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12130539	MGI
involved in regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	18599438	MGI
involved in regulation of germinal center formation	IMP IMP: Inferred from mutant phenotype	18438409	MGI
involved in regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	19211936	MGI
involved in regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	22496871	MGI
involved in regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	18599438	MGI
acts upstream of or within regulation of sarcomere organization	IMP IMP: Inferred from mutant phenotype	17875930	MGI
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	18599438	MGI
involved in regulation of synaptic activity	IMP IMP: Inferred from mutant phenotype	18599437	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	22496871	MGI
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	18599438	MGI
involved in renal tubule morphogenesis	IMP IMP: Inferred from mutant phenotype	20181743	MGI
acts upstream of or within roof of mouth development	IGI IGI: Inferred from genetic interaction	17420000	MGI
involved in secondary heart field specification	IMP IMP: Inferred from mutant phenotype	15890826	MGI
involved in semaphorin-plexin signaling pathway involved in axon guidance	IMP IMP: Inferred from mutant phenotype	30735130	MGI
involved in sinoatrial valve morphogenesis	IMP IMP: Inferred from mutant phenotype	16680724	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	17786239	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	9778514	MGI
involved in sympathetic neuron axon guidance	IMP IMP: Inferred from mutant phenotype	30735130	MGI
involved in ventricular cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16680724	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11081517	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myocyte-specific enhancer factor 2C

Mef2c Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Mef2c	Q8CFN5	HDAC7	Homo sapiens	Q8WUI4	Anti Bait CoIP	23565059
Intra	Mef2c	Q8CFN5	Hipk2	Mus musculus	Q9QZR5	Anti Bait CoIP	23565059

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120877	MRT199665		99.74%	Unkown
HY-120877A	(R)-MRT199665		98.70%	Unkown
HY-RS08311	MEF2C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mef2c	NCBI	NCBI:4208

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