SERPINB13 - serpin family B member 13 Gene

Homo sapiens

Also known as HUR7; PI13; headpin; HSHUR7SEQ

Gene ID: 5275 | Gene type: protein coding

About SERPINB13

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,587,343-63,599,192 (from NCBI)

This gene has 6 transcripts (splice variants), 82 orthologues and 36 paralogues. Restricted expression toward esophagus (RPKM 94.0).

Summary

The protein encoded by this gene is a member of the serpin family of serine Protease Inhibitors. The encoded protein inhibits the activity of Cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of Cancer. [provided by RefSeq, Jan 2017]

SERPINB13 Products(6)

mRNA	Protein	Name
NM_001307923.2	NP_001294852.1	serpin B13 isoform 1
NM_001348267.2	NP_001335196.1	serpin B13 isoform 3
NM_001348268.2	NP_001335197.1	serpin B13 isoform 3
NM_001348269.2	NP_001335198.1	serpin B13 isoform 4
NM_001348270.2	NP_001335199.1	serpin B13 isoform 4
NM_012397.4	NP_036529.1	serpin B13 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	12504904	GOA
enables cysteine-type endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	12809493	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	12504904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
NOT enables serine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	12504904	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of endopeptidase activity	IDA IDA: Inferred from direct assay	12504904	GOA
involved in negative regulation of keratinocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	12809493	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12809493	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	12809493	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12809493	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINB13 Protein Structure

Serpin

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

serpin B13

HURPIN

SERPINB13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SERPINB13	Q9UIV8	DLG2	Homo sapiens	Q15700	Y2H Prey Pooling	32296183
Intra	SERPINB13	Q9UIV8	DLG2	Homo sapiens	Q15700	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Psoriasis

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12709	SERPINB13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SERPINB13	VGNC	VGNC:34472
Macaca mulatta	SERPINB13	VGNC	VGNC:104246
Mus musculus	SERPINB13	MGD	MGI:3042250
Canis familiaris	SERPINB13	VGNC	VGNC:46029
Rattus norvegicus	SERPINB13	RGD	RGD:1304661

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