Ngfr - nerve growth factor receptor (TNFR superfamily, member 16) Gene

Mus musculus

Also known as p75; LNGFR; p75NTR; p75NGFR; Tnfrsf16

Gene ID: 18053 | Gene type: protein coding

About Ngfr

Summary

Enables death receptor activity; nerve growth factor binding activity; and small GTPase binding activity. Involved in several processes, including cellular glucose homeostasis; circadian regulation of gene expression; and dorsal aorta development. Acts upstream of or within several processes, including hair follicle morphogenesis; nervous system development; and regulation of signal transduction. Located in several cellular components, including cell surface; cell-cell junction; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ngfr Products(1)

mRNA	Protein	Name
NM_033217.3	NP_150086.2	tumor necrosis factor receptor superfamily member 16 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables death receptor activity	IDA IDA: Inferred from direct assay	10764727	MGI
enables nerve growth factor binding	IDA IDA: Inferred from direct assay	1317267	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10545116	MGI
enables small GTPase binding	IDA IDA: Inferred from direct assay	22460790	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	11978834	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	11978834	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23785138	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	23785138	MGI
acts upstream of or within detection of temperature stimulus	IMP IMP: Inferred from mutant phenotype	1317267	MGI
involved in dorsal aorta development	IMP IMP: Inferred from mutant phenotype	11559852	MGI
acts upstream of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10588868	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	10588868	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	22460790	MGI
acts upstream of hair follicle development	IMP IMP: Inferred from mutant phenotype	10588868	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	10588868	MGI
involved in intracellular glucose homeostasis	IMP IMP: Inferred from mutant phenotype	22460790	MGI
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	22460790	MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10588868	MGI
acts upstream of or within negative regulation of hair follicle development	IMP IMP: Inferred from mutant phenotype	10588868	MGI
acts upstream of or within nerve development	IMP IMP: Inferred from mutant phenotype	1317267	MGI
acts upstream of odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	9268129	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10764727	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	10588868	MGI
acts upstream of or within positive regulation of odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	9268129	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	31514753	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	31514753	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	10588868	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	1317267	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	10021336	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	21300049	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19295126	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	31514753	MGI
is active in neuromuscular junction	IMP IMP: Inferred from mutant phenotype	31514753	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10536054	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	24069373	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 16

NGF receptor	low affinity neurotrophin receptor p75NTR
low-affinity nerve growth factor receptor	p75 neurotrophin receptor

Recombinant Ngfr Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77100	NGFR Protein, Mouse (HEK293, Fc)	Q9Z0W1 (M1-N243)	≥95%
HY-P77101	NGFR Protein, Mouse (HEK293, His)	Q9Z0W1 (K32-N253)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111163	NSC49652	Inducer	99.92%	Unkown
HY-RS09278	NGFR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ngfr	NCBI	NCBI:4804
Leporidae	Ngfr	NCBI

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