2. Apoptosis
  3. Apoptosis
  4. NSC49652

NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells.

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NSC49652 Chemical Structure

NSC49652 Chemical Structure

CAS No. : 908563-68-8

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Based on 1 publication(s) in Google Scholar

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Description

NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells[1].

IC50 & Target

p75NTR, Apoptosis[1]
Molecular Weight

225.24

Formula

C14H11NO2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=CC=C1O)/C=C/C2=CC=CN=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20.83 mg/mL (92.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4397 mL 22.1985 mL 44.3971 mL
5 mM 0.8879 mL 4.4397 mL 8.8794 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4397 mL 22.1985 mL 44.3971 mL 110.9927 mL
5 mM 0.8879 mL 4.4397 mL 8.8794 mL 22.1985 mL
10 mM 0.4440 mL 2.2199 mL 4.4397 mL 11.0993 mL
15 mM 0.2960 mL 1.4799 mL 2.9598 mL 7.3995 mL
20 mM 0.2220 mL 1.1099 mL 2.2199 mL 5.5496 mL
25 mM 0.1776 mL 0.8879 mL 1.7759 mL 4.4397 mL
30 mM 0.1480 mL 0.7400 mL 1.4799 mL 3.6998 mL
40 mM 0.1110 mL 0.5550 mL 1.1099 mL 2.7748 mL
50 mM 0.0888 mL 0.4440 mL 0.8879 mL 2.2199 mL
60 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8499 mL
80 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3874 mL
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NSC49652 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC49652908563-68-8NSC 49652NSC-49652Apoptosisp75NTRNGFRTNFRSF16CD271melanomaantitumorInhibitorinhibitorinhibit

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