DPYSL3 - dihydropyrimidinase like 3 Gene

Homo sapiens

Also known as DRP3; ULIP; CRMP4; DRP-3; LCRMP; CRMP-4; ULIP-1

Gene ID: 1809 | Gene type: protein coding

About DPYSL3

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:147,390,808-147,510,068 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 5 paralogues. Broad expression in brain (RPKM 51.8), prostate (RPKM 49.3) and 22 other tissues.

Summary

Enables filamin binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including cell body; growth cone; and lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in synapse. Predicted to colocalize with exocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

DPYSL3 Products(2)

mRNA	Protein	Name
NM_001197294.2	NP_001184223.1	dihydropyrimidinase-related protein 3 isoform 1
NM_001387.3	NP_001378.1	dihydropyrimidinase-related protein 3 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables filamin binding	IPI IPI: Inferred from physical interaction	25358863	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPYSL3 Protein Structure

Amidohydro_1

0
100
200
300
400
500
570 a.a.

Protein Preferred Names

Protein Names

dihydropyrimidinase-related protein 3

collapsin response mediator protein 4 long

DPYSL3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DPYSL3	Q14195	DPYSL2	Homo sapiens	Q16555	Anti Tag CoIP	28514442
Intra	DPYSL3	Q14195	DPYSL2	Homo sapiens	Q16555	Anti Tag CoIP	33961781
Intra	DPYSL3	Q14195	DPYSL2	Homo sapiens	Q16555	Y2H Array	29892012
Intra	DPYSL3	Q14195	DPYSL2	Homo sapiens	Q16555	Y2H Array	31515488
Intra	DPYSL3	Q14195	ACD	Homo sapiens	Q96AP0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPYSL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71546	DPYSL3 Protein, Human (His)	Q14195 (1M-570S)	≥95%

DPYSL3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83032	CRMP4 Antibody (YA2777)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03982	DPYSL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DPYSL3	VGNC	VGNC:28196
Rattus norvegicus	DPYSL3	RGD	RGD:2410
Canis familiaris	DPYSL3	VGNC	VGNC:40084
Felis catus	DPYSL3	VGNC	VGNC:61616
Macaca mulatta	DPYSL3	VGNC	VGNC:71985
Mus musculus	DPYSL3	MGD	MGI:1349762
Others	DPYSL3	NCBI

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