Nqo1 - NAD(P)H dehydrogenase, quinone 1 Gene

Mus musculus

Also known as Dtd; Ox1; Qr1; Dia4; Nmo1; Ox-1; Nmo-1; Nmor1

Gene ID: 18104 | Gene type: protein coding

About Nqo1

Summary

Enables NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within negative regulation of catalytic activity and response to oxidative stress. Predicted to be located in cytoplasm; dendrite; and neuronal cell body. Predicted to be active in cytosol. Is expressed in heart; main olfactory bulb; olfactory epithelium; and skin. Human ortholog(s) of this gene implicated in several diseases, including asthma; hematologic Cancer (multiple); lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nqo1 Products(1)

mRNA	Protein	Name
NM_008706.5	NP_032732.3	NAD(P)H dehydrogenase [quinone] 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD(P)H dehydrogenase (quinone) activity	IDA IDA: Inferred from direct assay	1914521	MGI
enables NADH:ubiquinone reductase (non-electrogenic) activity	IDA IDA: Inferred from direct assay	8999809	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	29934320	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytokine production	IMP IMP: Inferred from mutant phenotype	29934320	MGI
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	29934320	MGI
acts upstream of or within negative regulation of catalytic activity	IDA IDA: Inferred from direct assay	10903442	MGI
involved in protein catabolic process	IDA IDA: Inferred from direct assay	29934320	MGI
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	29934320	MGI
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	29934320	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	15386390	MGI
involved in vitamin K metabolic process	IDA IDA: Inferred from direct assay	8999809	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	29934320	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	29934320	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NAD(P)H dehydrogenase [quinone] 1

DT-diaphorase	NAD(P)H dehydrogenase (quinone)
NAD(P)H menadione oxidoreductase 1, dioxin inducible	NAD(P)H:quinone oxidoreductase 1
azoreductase	diaphorase 4 (NADH/NADPH)
menadione reductase	phylloquinone reductase
quinone reductase 1

Recombinant Nqo1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71831	Azoreductase/NQO1 Protein, Mouse (P.pastoris, His)	Q64669 (A2-K274)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170947	Antitumor agent-195	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nqo1	NCBI	NCBI:1728

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