Nodal - nodal Gene

Mus musculus

Also known as Tg.413d

Gene ID: 18119 | Gene type: protein coding

About Nodal

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. Homozygous knockout mice for this gene exhibit early embryonic lethality, while expression of a hypomorphic allele results in defects in anteroposterior and left-right patterning. [provided by RefSeq, Aug 2016]

Nodal Products(1)

mRNA	Protein	Name
NM_013611.5	NP_038639.2	nodal preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12052855	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	12052855	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	7924997	MGI
acts upstream of or within anterior/posterior axis specification	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	16496285	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within axial mesodermal cell fate specification	IMP IMP: Inferred from mutant phenotype	14511481	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of cell differentiation	IDA IDA: Inferred from direct assay	11456449	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	12842913	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	15302604	MGI
acts upstream of or within cell migration involved in gastrulation	IDA IDA: Inferred from direct assay	15004567	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15004567	MGI
involved in determination of left/right asymmetry in lateral mesoderm	IMP IMP: Inferred from mutant phenotype	17507406	MGI
acts upstream of or within determination of left/right symmetry	IDA IDA: Inferred from direct assay	12642485	MGI
acts upstream of or within determination of left/right symmetry	IGI IGI: Inferred from genetic interaction	15466485	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within digestive system development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	11456449	MGI
acts upstream of or within embryonic process involved in female pregnancy	IMP IMP: Inferred from mutant phenotype	11456449	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification	IMP IMP: Inferred from mutant phenotype	14511481	MGI
acts upstream of or within floor plate morphogenesis	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within formation of anatomical boundary	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within gastrulation	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	14607953	MGI
acts upstream of germ cell development	IMP IMP: Inferred from mutant phenotype	23034635	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within heart looping	IGI IGI: Inferred from genetic interaction	16496285	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16678814	MGI
acts upstream of or within left lung morphogenesis	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within maternal placenta development	IMP IMP: Inferred from mutant phenotype	22378764	MGI
acts upstream of or within maternal process involved in parturition	IMP IMP: Inferred from mutant phenotype	22378764	MGI
acts upstream of or within mesendoderm development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within negative regulation of cell development	IMP IMP: Inferred from mutant phenotype	23034635	MGI
acts upstream of or within negative regulation of cell differentiation	IDA IDA: Inferred from direct assay	11456449	MGI
acts upstream of or within negative regulation of reproductive process	IMP IMP: Inferred from mutant phenotype	23034635	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11456449	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within neural fold formation	IMP IMP: Inferred from mutant phenotype	11311163	MGI
involved in nodal signaling pathway	IMP IMP: Inferred from mutant phenotype	12052855	MGI
acts upstream of or within polarity specification of proximal/distal axis	IMP IMP: Inferred from mutant phenotype	14511481	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	21116837	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15004567	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17507406	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17568773	MGI
acts upstream of or within primitive streak formation	IGI IGI: Inferred from genetic interaction	21445260	MGI
acts upstream of or within regulation of gastrulation	IGI IGI: Inferred from genetic interaction	20040491	MGI
acts upstream of or within regulation of signal transduction	IDA IDA: Inferred from direct assay	17936261	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: Inferred from genetic interaction	15505202	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	16678814	MGI
acts upstream of or within stem cell population maintenance	IGI IGI: Inferred from genetic interaction	15505202	MGI
acts upstream of or within tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	11311163	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14511481	MGI
acts upstream of or within trophectodermal cell differentiation	IDA IDA: Inferred from direct assay	11456449	MGI
acts upstream of or within trophectodermal cellular morphogenesis	IMP IMP: Inferred from mutant phenotype	11456449	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	11311163	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	12052855	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nodal

Recombinant Nodal Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79080	Nodal Protein, Mouse	P43021 (H245-L354)	≥95%

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0016	Dronedarone		99.93%	Unkown
HY-17611	Etripamil	Antagonist	98.80%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106577	Cibenzoline		99.96%	Phase 4

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10432	A 83-01	Inhibitor	99.33%	Unkown
HY-10432R	A 83-01 (Standard)	Inhibitor	/	Unkown
HY-RS09409	NODAL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-123196	CVT-2759	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nodal	NCBI	NCBI:4838

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