Musk - muscle, skeletal, receptor tyrosine kinase Gene

Mus musculus

Also known as Mlk; Mdk4; Nsk1; Nsk2; Nsk3

Gene ID: 18198 | Gene type: protein coding

About Musk

Summary

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Musk Products(6)

mRNA	Protein	Name
NM_001037127.2	NP_001032204.2	muscle, skeletal receptor tyrosine-protein kinase isoform 1
NM_001037128.1	NP_001032205.1	muscle, skeletal receptor tyrosine-protein kinase isoform 2
NM_001037129.1	NP_001032206.1	muscle, skeletal receptor tyrosine-protein kinase isoform 3
NM_001037130.1	NP_001032207.1	muscle, skeletal receptor tyrosine-protein kinase isoform 5
NM_001165996.1	NP_001159468.1	muscle, skeletal receptor tyrosine-protein kinase isoform 6
NM_010944.2	NP_035074.2	muscle, skeletal receptor tyrosine-protein kinase isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	17576800	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12165471	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	14622576	MGI
enables protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	14622576	MGI
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	8653787	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in enzyme-linked receptor protein signaling pathway	IDA IDA: Inferred from direct assay	18848351	MGI
involved in enzyme-linked receptor protein signaling pathway	IGI IGI: Inferred from genetic interaction	8653787	MGI
involved in enzyme-linked receptor protein signaling pathway	IMP IMP: Inferred from mutant phenotype	14622576	MGI
acts upstream of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11312299	MGI
acts upstream of or within neuromuscular junction development	IGI IGI: Inferred from genetic interaction	12165471	MGI
involved in positive regulation of Rac protein signal transduction	IDA IDA: Inferred from direct assay	16794080	MGI
involved in positive regulation of Rac protein signal transduction	IGI IGI: Inferred from genetic interaction	14622576	MGI
involved in positive regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	8653787	MGI
acts upstream of or within positive regulation of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11312299	MGI
involved in positive regulation of protein geranylgeranylation	IMP IMP: Inferred from mutant phenotype	14622576	MGI
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	14622576	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IDA IDA: Inferred from direct assay	18848351	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IGI IGI: Inferred from genetic interaction	8653787	MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	14622576	MGI
acts upstream of or within receptor clustering	IGI IGI: Inferred from genetic interaction	12165471	MGI
acts upstream of or within receptor clustering	IMP IMP: Inferred from mutant phenotype	11395002	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10320756	MGI
acts upstream of or within regulation of synaptic assembly at neuromuscular junction	IMP IMP: Inferred from mutant phenotype	8653786	MGI
involved in skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	11323662	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	20053883	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	14622576	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	17119023	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	14678832	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	9136771	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	19038220	MGI
located in synapse	IDA IDA: Inferred from direct assay	20053883	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

muscle, skeletal receptor tyrosine-protein kinase

muscle localized kinase 2	muscle-specific kinase receptor
muscle-specific tyrosine-protein kinase receptor

Musk Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Musk	Q61006	Dok7	Mus musculus	Q18PE0	X-Ray Diffraction	20603078

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Musk Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71568	MUSK Protein, Mouse (Myc, His-SUMO)	Q61006 (E22-S494)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0633	Muscone	Inhibitor	≥98.0%	Unkown
HY-15590	AZ-23	Inhibitor	98.92%	Unkown
HY-N2045	Musk ketone		99.41%	Unkown
HY-N3127	Orobol	Inhibitor	99.28%	Unkown
HY-116108	Musk tibetene		/	Unkown
HY-RS08852	MUSK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Musk	NCBI	NCBI:4593
Macaca fascicularis	Musk	NCBI	NCBI:102127677

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