2. Gene
  3. Musk - muscle, skeletal, receptor tyrosine kinase Gene

Musk - muscle, skeletal, receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mlk; Mdk4; Nsk1; Nsk2; Nsk3

Gene ID: 18198 | Gene type: protein coding

About Musk

Summary

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Musk Products(6)

mRNA Protein Name
NM_001037127.2 NP_001032204.2 muscle, skeletal receptor tyrosine-protein kinase isoform 1
NM_001037128.1 NP_001032205.1 muscle, skeletal receptor tyrosine-protein kinase isoform 2
NM_001037129.1 NP_001032206.1 muscle, skeletal receptor tyrosine-protein kinase isoform 3
NM_001037130.1 NP_001032207.1 muscle, skeletal receptor tyrosine-protein kinase isoform 5
NM_001165996.1 NP_001159468.1 muscle, skeletal receptor tyrosine-protein kinase isoform 6
NM_010944.2 NP_035074.2 muscle, skeletal receptor tyrosine-protein kinase isoform 4
Protein Preferred Names Protein Names

muscle, skeletal receptor tyrosine-protein kinase

muscle localized kinase 2

muscle-specific kinase receptor

muscle-specific tyrosine-protein kinase receptor

Recombinant Musk Proteins

Cat. No. Product Name Accession Purity
HY-P71568 MUSK Protein, Mouse (Myc, His-SUMO) Q61006 (E22-S494) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0633 Muscone Inhibitor ≥98.0% Unkown
HY-15590 AZ-23 Inhibitor 98.92% Unkown
HY-N2045 Musk ketone 99.41% Unkown
HY-N3127 Orobol Inhibitor 99.28% Unkown
HY-116108 Musk tibetene / Unkown
HY-RS08852 MUSK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Musk NCBI NCBI:4593
Macaca fascicularis Musk NCBI NCBI:102127677