2. Membrane Transporter/Ion Channel Immunology/Inflammation Apoptosis NF-κB
  3. P-glycoprotein Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)
  4. Muscone

Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.

For research use only. We do not sell to patients.

Muscone Chemical Structure

Muscone Chemical Structure

CAS No. : 541-91-3

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Muscone:

Muscone Related Antibodies

Top Publications Citing Use of Products

    Muscone purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2023 Mar 5.

    Muscone (8 mg/kg; i.p.; once a day for 7 consecutive days) significantly decreases the expression levels of pro-inflammatory proteins including TNF-α, IL-1β and IL-6 in mice distal middle cerebral artery occlusion (dMCAO) model.

    Muscone purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2023 Mar 5.

    Muscone (8 mg/kg; i.p.; once a day for 7 consecutive days) obviously reduces the infarct volume in mice.

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    TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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    NLRP3 NLRP1 NOD1 NOD2

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1].

    IC50 & Target[1]

    NF-κB

     

    NLRP3

     

    IL-1β

     

    IL-6

     

    In Vitro

    Muscone significantly downregulates the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in Bone marrow-derived macrophages (BMDMs). Muscone serves as a promising and effective drug for post-myocardial infarction (MI) treatment[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Muscone Related Antibodies
    Molecular Weight

    238.41

    Formula

    C16H30O
    CAS No.
    Appearance

    Liquid (Density: 0.9221 g/cm3)

    Color

    Colorless to light yellow

    SMILES

    O=C1CC(C)CCCCCCCCCCCC1
    Structure Classification
    Initial Source

    musk
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (419.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.1945 mL 20.9723 mL 41.9445 mL
    5 mM 0.8389 mL 4.1945 mL 8.3889 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
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    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: ≥98.0%

    COA (252 KB) HNMR (245 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.1945 mL 20.9723 mL 41.9445 mL 104.8614 mL
    5 mM 0.8389 mL 4.1945 mL 8.3889 mL 20.9723 mL
    10 mM 0.4194 mL 2.0972 mL 4.1945 mL 10.4861 mL
    15 mM 0.2796 mL 1.3982 mL 2.7963 mL 6.9908 mL
    20 mM 0.2097 mL 1.0486 mL 2.0972 mL 5.2431 mL
    25 mM 0.1678 mL 0.8389 mL 1.6778 mL 4.1945 mL
    30 mM 0.1398 mL 0.6991 mL 1.3982 mL 3.4954 mL
    40 mM 0.1049 mL 0.5243 mL 1.0486 mL 2.6215 mL
    50 mM 0.0839 mL 0.4194 mL 0.8389 mL 2.0972 mL
    60 mM 0.0699 mL 0.3495 mL 0.6991 mL 1.7477 mL
    80 mM 0.0524 mL 0.2622 mL 0.5243 mL 1.3108 mL
    100 mM 0.0419 mL 0.2097 mL 0.4194 mL 1.0486 mL
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    Muscone Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Muscone541-91-3P-glycoproteinInterleukin RelatedTNF ReceptorNF-κBNOD-like Receptor (NLR)P-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243ILTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBanti-inflammationmyocardialinfarctionmacrophageNLRP3inflammasomeIL-1βTNF-αIL-6Inhibitorinhibitorinhibit

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