Sigmar1 - sigma non-opioid intracellular receptor 1 Gene

Mus musculus

Also known as Oprs1; Sig1R; sigma1R

Gene ID: 18391 | Gene type: protein coding

About Sigmar1

Chromosome 4: 41,738,493-41,756,157 reverse strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 206 orthologues and is associated with 7 phenotypes. Ubiquitous expression in liver adult (RPKM 37.), subcutaneous fat pad adult (RPKM 22.3) and 28 other tissues.

Summary

This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]

Sigmar1 Products(8)

mRNA	Protein	Name
NM_001286539.1	NP_001273468.1	sigma non-opioid intracellular receptor 1 isoform 3
NM_001286540.1	NP_001273469.1	sigma non-opioid intracellular receptor 1 isoform 4
NM_011014.3	NP_035144.1	sigma non-opioid intracellular receptor 1 isoform 1
NM_001286605.1	NP_001273534.1	sigma non-opioid intracellular receptor 1 isoform 7
NM_001286551.1	NP_001273480.1	sigma non-opioid intracellular receptor 1 isoform 7
NM_001286538.1	NP_001273467.1	sigma non-opioid intracellular receptor 1 isoform 2
NM_001286541.1	NP_001273470.1	sigma non-opioid intracellular receptor 1 isoform 5
NM_001286542.1	NP_001273471.1	sigma non-opioid intracellular receptor 1 isoform 6

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17981125	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	14622179	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in postsynapse	IDA IDA: Inferred from direct assay	20167253	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	20167253	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sigmar1 Protein Structure

ERG2_Sigma1R

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

sigma non-opioid intracellular receptor 1

opioid receptor, sigma 1	sigma 1 receptor variant SR-1D
sigma 1-type opioid receptor	sigma1-receptor

Sigmar1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sigmar1	O55242	Kcna2	Mus musculus	P63141	Confocal	23332758
Intra	Sigmar1	O55242	Kcna2	Mus musculus	P63141	Crosslink	23332758
Cross	Sigmar1	O55242	HSPA5	Cricetulus griseus	G3I8R9	Immunodepletion CoIP	17981125
Cross	Sigmar1	O55242	HSPA5	Cricetulus griseus	G3I8R9	Anti Bait CoIP	17981125

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12908	SIGMAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12909	Sigmar1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12910	Sigmar1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sigmar1	NCBI	NCBI:10280

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