2. Gene
  3. DUSP7 - dual specificity phosphatase 7 Gene

DUSP7 - dual specificity phosphatase 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MKPX; PYST2

Gene ID: 1849 | Gene type: protein coding

About DUSP7

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:52,048,919-52,056,571 (from NCBI)

This gene has 2 transcripts (splice variants), 203 orthologues and 30 paralogues. Ubiquitous expression in esophagus (RPKM 18.5), skin (RPKM 16.3) and 24 other tissues.

Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, Apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP7 Products(1)

mRNA Protein Name
NM_001947.4 NP_001938.2 dual specificity protein phosphatase 7
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables MAP kinase tyrosine/serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
9788880 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9788880 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
9788880 GOA
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
9788880 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
9788880 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP7 Protein Structure

Rhodanese

Rhodanese: Rhodanese-like domain (56 - 180)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (252 - 383)

  • 0
  • 100
  • 200
  • 300
  • 419 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 7

dual specificity protein phosphatase PYST2

Related Diseases

Diseases Alias
Variola Major

Smallpox
Erythrocytosis, Familial, 7

ECYT7

Erythrocytosis 7

Familial Erythrocytosis 7

Erythrocytosis, Alpha-Globin Type

Polycythemia, Alpha-Globin Type

Alpha-Globin Type Erythrocytosis

Alpha-Globin Type Polycythemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122615B SPOP-IN-6b dihydrochloride Inhibitor 99.70% Unkown
HY-156382 SPOP-IN-1 Inhibitor 99.71% Unkown
HY-122615A SPOP-IN-6b hydrochloride Inhibitor / Unkown
HY-RS04068 DUSP7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DUSP7 VGNC VGNC:61670
Mus musculus DUSP7 MGD MGI:2387100
Bos taurus DUSP7 VGNC VGNC:28263
Canis familiaris DUSP7 VGNC VGNC:40136
Macaca mulatta DUSP7 VGNC VGNC:82137
Rattus norvegicus DUSP7 RGD RGD:735026