2. Gene
  3. Pgf - placental growth factor Gene

Pgf - placental growth factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PIGF; Plgf

Gene ID: 18654 | Gene type: protein coding

About Pgf

Summary

Predicted to enable identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor binding activity. Acts upstream of or within branching involved in ureteric bud morphogenesis and regulation of morphogenesis of a branching structure. Located in extracellular space. Is expressed in several structures, including brain; gut gland; musculature; reproductive system; and urinary system. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Orthologous to human PGF (placental growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Pgf Products(2)

mRNA Protein Name
NM_001271705.1 NP_001258634.1 placenta growth factor isoform 2
NM_008827.3 NP_032853.1 placenta growth factor isoform 1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within branching involved in ureteric bud morphogenesis IDA
IDA: Inferred from direct assay
13678594 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
30179860 MGI
acts upstream of or within glycogen metabolic process IGI
IGI: Inferred from genetic interaction
30179860 MGI
acts upstream of or within glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
30179860 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
30179860 MGI
acts upstream of or within regulation of blood pressure IGI
IGI: Inferred from genetic interaction
30179860 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
30179860 MGI
acts upstream of or within regulation of morphogenesis of a branching structure IDA
IDA: Inferred from direct assay
13678594 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
25184477 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

placenta growth factor

Recombinant Pgf Proteins

Cat. No. Product Name Accession Purity
HY-P70792 PLGF Protein, Mouse (HEK293, His) P49764 (V19-P158) ≥95%
HY-P78337 PLGF Protein, Mouse (HEK293, Fc) P49764 (V19-P158) ≥95%

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12956 Dinoprost 99.63% Unkown
HY-12956A Dinoprost tromethamine salt ≥98.0% Unkown
HY-128428 Carboprost 99.83% Unkown
HY-116733 Tafluprost ethyl ester Agonist / Unkown
HY-124219 17-Phenoxy trinor prostaglandin F2α ethyl amide Agonist / Unkown
HY-158571 17-Phenoxy trinor prostaglandin F2α / Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101438 Darbufelone Inhibitor ≥98.0% Phase 3
HY-112284 Ebopiprant Antagonist 98.65% Phase 2
Pre-clinical Phase
Bioactive Molecules (89)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100449 AL-8810 99.00% Unkown
HY-114379 AS2717638 Antagonist 99.53% Unkown
HY-107381 (+)-Cloprostenol Agonist 99.28% Unkown
HY-108415 Cloprostenol sodium salt Agonist 99.52% Unkown
HY-101438A Darbufelone mesylate Inhibitor 99.65% Unkown
HY-111478 Tiaprost ≥98.0% Unkown
HY-113209S 8-Iso-PGF2a-d4 / Unkown
HY-113246 15-keto-Prostaglandin F2a 99.2% Unkown
HY-125774S Bimatoprost acid-d4 95.25% Unkown
HY-12956S Dinoprost-d4 ≥99.0% Unkown
HY-132277S 15-Keto Bimatoprost-d5 96.65% Unkown
HY-113208 13,14-Dihydro-15-keto Prostaglandin F2α ≥99.0% Unkown
HY-116161A 17-Phenyl trinor PGF2α isopropyl ester 99.76% Unkown
HY-105953 Froxiprost / Unkown
HY-106037 PGF2α-isopropyl ester / Unkown
HY-108415R Cloprostenol sodium salt (Standard) Agonist / Unkown
HY-113208A 11β-13,14-Dihydro-15-keto Prostaglandin F2α / Unkown
HY-113208AS1 11β-13,14-Dihydro-15-keto Prostaglandin F2α-d4 / Unkown
HY-113459S1 13,14-Dihydro-15-keto Prostaglandin F2α-d4 / Unkown
HY-113778 15-keto-17-phenyl trinor Prostaglandin F2α / Unkown
HY-113887 Prostaglandin F1β / Unkown
HY-113887A 11β-Prostaglandin F1β / Unkown
HY-113887S Prostaglandin F1β-d9 / Unkown
HY-113909 Dinoprost (methoxyamine) / Unkown
HY-114687 5,7-Dihydroxy-11-ketotetranorprostanoic acid / Unkown
HY-114850 5-trans Prostaglandin F2β / Unkown
HY-114850A (5R)-Dinoprost tromethamine / Unkown
HY-116051 16,16-Dimethylprostaglandin F2α / Unkown
HY-116051A 16,16-Dimethylprostaglandin F2β / Unkown
HY-116161 Bimatoprost isopropyl ester / Unkown
HY-118648 Prostaglandin F2α methyl ester / Unkown
HY-120197 17-Phenyl trinor prostaglandin F2α methyl amide / Unkown
HY-121314 Cloprostenol / Unkown
HY-124085 Prostaglandin F1α alcohol / Unkown
HY-125150 AL-3138 Antagonist / Unkown
HY-125396 11-Deoxyprostaglandin F2β / Unkown
HY-125626 8-iso-15-keto Prostaglandin F2α Agonist / Unkown
HY-126762 Fenprostalene / Unkown
HY-129397S 2,3-Dinor-11β-prostaglandin F2α-d9 / Unkown
HY-12956B (5R)-Dinoprost / Unkown
HY-12956S1 Dinoprost-d9 / Unkown
HY-12956S2 Dinoprost-13C5 / Unkown
HY-131617 Prostaglandin F2α 1,11-lactone / Unkown
HY-131632 1a,1b-Dihomo prostaglandin F2α / Unkown
HY-131696 11-deoxy Prostaglandin F1α / Unkown
HY-131729 16-Phenoxy tetranor Prostaglandin A2 / Unkown
HY-132277 15-Keto Bimatoprost / Unkown
HY-136494 Fluprostenol / Unkown
HY-137024 15-Keto-PGA1 / Unkown
HY-137412 PGF2α 1,15-lactone / Unkown
HY-138244 8-iso Prostaglandin F2β / Unkown
HY-139119 Prostaglandin F2α dimethyl amide Antagonist / Unkown
HY-149502 8-Iso-15(R)-prostaglandin F2α / Unkown
HY-149588 17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester / Unkown
HY-157660 15(R)-Prostaglandin F1α / Unkown
HY-158595 15(R),19(R)-Hydroxy prostaglandin F2α / Unkown
HY-163376 17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide / Unkown
HY-163784 AKR1C3-IN-14 Inhibitor / Unkown
HY-N12119 ent-Prostaglandin F2α / Unkown
HY-RS10381 PGF Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W399193 PGF2α 1,9-lactone / Unkown
HY-W746888 17-Phenyl trinor prostaglandin F2α diethyl amide / Unkown
HY-100449A (S)-AL-8810 Antagonist / Unkown
HY-105142 M-5011 / Unkown
HY-112284A Ebopiprant hydrochloride Antagonist / Unkown
HY-114656 Dihydro-PGF1α / Unkown
HY-114841 ONO 207 / Unkown
HY-114867 (15R)-Bimatoprost / Unkown
HY-116008 8-iso Prostaglandin F3α / Unkown
HY-116549 Prostaglandin F2α alcohol / Unkown
HY-116591 8-Iso-15-keto prostaglandin F2β / Unkown
HY-116679 17-trifluoromethylphenyl trinor Prostaglandin F2α / Unkown
HY-117717 (Rac)-SC-31391 Activator / Unkown
HY-118294 15-OH Tafluprost / Unkown
HY-118652 Δ17-6-keto Prostaglandin F1α / Unkown
HY-118754 13,14-Dihydro-15-keto PGF1α / Unkown
HY-118765 Ro 23-3423 / Unkown
HY-118816 11β-Prostaglandin F2α / Unkown
HY-120982 (+)-15-epi Cloprostenol / Unkown
HY-124175 16-Phenoxy prostaglandin F2α ethyl amide / Unkown
HY-124209 9-keto Fluprostenol / Unkown
HY-125774 Bimatoprost acid Agonist / Unkown
HY-129764 Prostaglandin F3α / Unkown
HY-129764A (17E)-Prostaglandin F3α / Unkown
HY-137547 20-Hydroxy-PGF2α / Unkown
HY-139063 16-Phenoxy tetranor prostaglandin F2α / Unkown
HY-139121 15(R)-17-Phenyl trinor Prostaglandin F2α / Unkown
HY-139124 15(R)-15-Methyl Prostaglandin F2α / Unkown
HY-158937 15(R)-15-Methyl prostaglandin F2α methyl ester / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pgf NCBI NCBI:5228
Macaca fascicularis Pgf NCBI NCBI:102134620
Macaca mulatta Pgf NCBI NCBI:701219