Ppp2ca - protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Gene

Mus musculus

Also known as PP2A

Gene ID: 19052 | Gene type: protein coding

About Ppp2ca

Summary

Enables GABA Receptor binding activity and protein C-terminus binding activity. Acts upstream of or within mesoderm development. Located in chromosome, centromeric region; cytosol; and plasma membrane. Part of protein Phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PPP2CA (protein Phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp2ca Products(1)

mRNA	Protein	Name
NM_019411.4	NP_062284.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GABA receptor binding	IDA IDA: Inferred from direct assay	16754670	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9920888	MGI
enables protein serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	26974206	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	26974206	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	9770493	MGI
involved in negative regulation of glycolytic process through fructose-6-phosphate	IMP IMP: Inferred from mutant phenotype	32192773	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	26974206	MGI
involved in positive regulation of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	28465465	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	18084284	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	9882488	MGI
located in cytosol	IDA IDA: Inferred from direct assay	12885400	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10781942	MGI
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	16717086	MGI
is active in synapse	IDA IDA: Inferred from direct assay	16420440	MGI
is active in synapse	IEP IEP: Inferred from expression pattern	16420440	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

PP2A-alpha

Ppp2ca Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ppp2ca	P63330	Ppp2r1a	Mus musculus	Q76MZ3	Anti Bait CoIP	19818709
Intra	Ppp2ca	P63330	Igbp1	Mus musculus	Q61249	Anti Bait CoIP	19818709

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11007	PPP2CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp2ca	NCBI	NCBI:5515

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