Igbp1 - immunoglobulin (CD79A) binding protein 1 Gene

Mus musculus

Also known as p52; Pc52; Tap42

Gene ID: 18518 | Gene type: protein coding

About Igbp1

Summary

Enables mitogen-activated protein kinase kinase binding activity and protein domain specific binding activity. Involved in negative regulation of protein dephosphorylation; positive regulation of dephosphorylation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic signaling pathway. Located in cytoplasm and microtubule. Is expressed in bladder; female associated reproductive structure; ovary; ureter; and urethra of female. Human ortholog(s) of this gene implicated in corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome. Orthologous to human IGBP1 (immunoglobulin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Igbp1 Products(1)

mRNA	Protein	Name
NM_008784.3	NP_032810.4	immunoglobulin-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	11806752	MGI
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	17438131	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12963337	MGI
enables protein domain specific binding	IDA IDA: Inferred from direct assay	11806752	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15499020	MGI
involved in positive regulation of dephosphorylation	IMP IMP: Inferred from mutant phenotype	15499020	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15499020	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11806752	MGI
located in microtubule	IGI IGI: Inferred from genetic interaction	11806752	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

immunoglobulin-binding protein 1

CD79a-binding protein 1	alpha 4
alpha4 phosphoprotein	lymphocyte signal transduction molecule alpha 4
phosphoprotein, component, 52 kDa	protein phosphatase 2/4/6 regulatory subunit

Igbp1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Igbp1	Q61249	Ppp2ca	Mus musculus	P63330	Anti Bait CoIP	19818709
Cross	Igbp1	Q61249	PPP2CA	Homo sapiens	P67775	CoIP	12963337

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06612	IGBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igbp1	NCBI	NCBI:3476

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