PPP2CA - protein phosphatase 2 catalytic subunit alpha Gene

Homo sapiens

Also known as RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha

Gene ID: 5515 | Gene type: protein coding

About PPP2CA

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,194,332-134,226,073 (from NCBI)

This gene has 12 transcripts (splice variants), 287 orthologues, 12 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 63.8), bone marrow (RPKM 57.1) and 25 other tissues.

Summary

This gene encodes the Phosphatase 2A catalytic subunit. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

PPP2CA Products(4)

mRNA	Protein	Name
NM_001355019.2	NP_001341948.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2
NM_002715.4	NP_002706.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1
NM_001355019.2	NP_001341948.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2
NM_002715.4	NP_002706.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1

PPP2CA Protein Structure

Metallophos

0
100
200
309 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

PP2A-alpha

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder And Language Delay With Or Without Structural Brain Abnormalities

NEDLBA

Alzheimer Disease 15

AD15	Alzheimer'S Disease 15
Alzheimer Disease Without Neurofibrillary Tangles	Alzheimer'S Disease 15, Late Onset
Alzheimer'S Disease Without Neurofibrillary Tangles

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11007	PPP2CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP2CA	VGNC	VGNC:33251
Mus musculus	PPP2CA	MGD	MGI:1321159
Felis catus	PPP2CA	VGNC	VGNC:102292
Rattus norvegicus	PPP2CA	RGD	RGD:3380
Others	PPP2CA	NCBI

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