2. Gene
  3. Proc - protein C Gene

Proc - protein C Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PC

Gene ID: 19123 | Gene type: protein coding

About Proc

Summary

This gene encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The encoded protein undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease that degrades activated coagulation factors. A complete lack of the encoded protein in mice results in severe perinatal consumptive coagulopathy in the brain and liver, resulting in death within 24 hours after birth. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]

Proc Products(4)

mRNA Protein Name
NM_001042767.3 NP_001036232.1 vitamin K-dependent protein C isoform 2 preproprotein
NM_001042768.3 NP_001036233.2 vitamin K-dependent protein C isoform 3 precursor
NM_001313938.1 NP_001300867.1 vitamin K-dependent protein C isoform 2 preproprotein
NM_008934.4 NP_032960.3 vitamin K-dependent protein C isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IDA
IDA: Inferred from direct assay
9616155 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
9788960 MGI
acts upstream of or within negative regulation of blood coagulation IDA
IDA: Inferred from direct assay
9616155 MGI
acts upstream of or within negative regulation of blood coagulation IMP
IMP: Inferred from mutant phenotype
9788960 MGI
acts upstream of or within regulation of circulating fibrinogen levels IMP
IMP: Inferred from mutant phenotype
9788960 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vitamin K-dependent protein C

anticoagulant protein C

autoprothrombin IIA

blood coagulation factor XIV

inactivator of coagulation factors Va, VIII

Recombinant Proc Proteins

Cat. No. Product Name Accession Purity
HY-P74236 Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His) P33587 (I19-L460) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99229 Upifitamab 98.77% Phase 2
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11190 PROC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-E70438 Endoproteinase Pro-C / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99705 Lifastuzumab vedotin / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Proc NCBI NCBI:5624
Macaca fascicularis Proc NCBI NCBI:102136210
Rattus norvegicus Proc NCBI NCBI:25268