2. Gene
  3. Proc - protein C, inactivator of coagulation factors Va and VIIIa Gene

Proc - protein C, inactivator of coagulation factors Va and VIIIa Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 25268 | Gene type: protein coding

About Proc

Summary

Enables oligopeptidase activity and protein self-association. Involved in liver development; negative regulation of blood coagulation; and proteolysis. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; artery disease (multiple); placental abruption; thrombophilia (multiple); and toxic shock syndrome. Orthologous to human PROC (protein C, inactivator of coagulation factors Va and VIIIa). [provided by Alliance of Genome Resources, Apr 2022]

Proc Products(1)

mRNA Protein Name
NM_012803.1 NP_036935.1 vitamin K-dependent protein C precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IDA
IDA: Inferred from direct assay
1440533 RGD
enables oligopeptidase activity IDA
IDA: Inferred from direct assay
1440533 RGD
Biological Process GO Annotation Evidence Reference Source
involved in liver development IEP
IEP: Inferred from expression pattern
7660357 RGD
involved in negative regulation of blood coagulation IDA
IDA: Inferred from direct assay
1440533 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
1440533 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
16522789 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vitamin K-dependent protein C

anticoagulant protein C

autoprothrombin IIA

blood coagulation factor XIV

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99229 Upifitamab 98.77% Phase 2
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11190 PROC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-E70438 Endoproteinase Pro-C / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99705 Lifastuzumab vedotin / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Proc NCBI NCBI:5624
Macaca fascicularis Proc NCBI NCBI:102136210
Mus musculus Proc NCBI NCBI:19123