PGAM5 - PGAM family member 5, mitochondrial serine/threonine protein phosphatase Gene

Homo sapiens

Also known as BXLBV68

Gene ID: 192111 | Gene type: protein coding

About PGAM5

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,710,842-132,722,734 (from NCBI)

This gene has 5 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in esophagus (RPKM 6.8), testis (RPKM 6.7) and 25 other tissues.

Summary

Enables GTPase activator activity and protein serine/threonine Phosphatase activity. Involved in necroptotic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

PGAM5 Products(3)

mRNA	Protein	Name
NM_001170543.2	NP_001164014.1	serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1
NM_001170544.2	NP_001164015.1	serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 2
NM_138575.4	NP_612642.2	serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	22265414	GOA
enables phosphoprotein phosphatase activity	IMP IMP: Inferred from mutant phenotype	22265414	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19590015	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	19590015	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	22265414	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in necroptotic process	IMP IMP: Inferred from mutant phenotype	22265414	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	22915595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGAM5 Protein Structure

His_Phos_1

0
100
200
289 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase PGAM5, mitochondrial

Bcl-XL-binding protein v68

Related Diseases

Diseases

Alias

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139598	LFHP-1c	Inhibitor	98.07%	Unkown
HY-RS10376	PGAM5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PGAM5	VGNC	VGNC:100087
Bos taurus	PGAM5	VGNC	VGNC:32780
Mus musculus	PGAM5	MGD	MGI:1919792
Rattus norvegicus	PGAM5	RGD	RGD:1312028
Canis familiaris	PGAM5	VGNC	VGNC:52956
Others	PGAM5	NCBI

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