Nlgn1 - neuroligin 1 Gene

Mus musculus

Also known as NL1; Nlg1; mKIAA1070; 6330415N05Rik

Gene ID: 192167 | Gene type: protein coding

About Nlgn1

Summary

Enables neurexin family protein binding activity. Involved in several processes, including positive regulation of transport; synapse organization; and synaptic vesicle cycle. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of respiratory gaseous exchange by nervous system process; and synapse organization. Located in external side of plasma membrane and synapse. Is integral component of plasma membrane. Part of receptor complex. Is active in glutamatergic synapse. Is expressed in blood vessel and brain. Used to study autism spectrum disorder. Orthologous to human NLGN1 (neuroligin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn1 Products(5)

mRNA	Protein	Name
NM_001163387.2	NP_001156859.1	neuroligin-1 isoform 2
NM_001357095.1	NP_001344024.1	neuroligin-1 isoform 3
NM_001357096.1	NP_001344025.1	neuroligin-1 isoform 4
NM_001357097.1	NP_001344026.1	neuroligin-1 isoform 4
NM_138666.4	NP_619607.2	neuroligin-1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neurexin family protein binding	IMP IMP: Inferred from mutant phenotype	10892652	MGI
enables neurexin family protein binding	IPI IPI: Inferred from physical interaction	12796785	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18084303	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in AMPA glutamate receptor clustering	IDA IDA: Inferred from direct assay	12796785	MGI
involved in AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	21940442	MGI
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	12796785	MGI
involved in cytoskeletal matrix organization at active zone	IMP IMP: Inferred from mutant phenotype	19628693	MGI
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	12796785	MGI
involved in excitatory synapse assembly	IDA IDA: Inferred from direct assay	22960622	MGI
involved in excitatory synapse assembly	IMP IMP: Inferred from mutant phenotype	26440732	MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	12796785	MGI
NOT involved in inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17582332	MGI
acts upstream of or within modulation of chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	16982420	MGI
involved in negative regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	23143522	MGI
involved in nervous system development	IDA IDA: Inferred from direct assay	10892652	MGI
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	28841651	MGI
involved in neurexin clustering involved in presynaptic membrane assembly	IDA IDA: Inferred from direct assay	12796785	MGI
involved in neuron cell-cell adhesion	IDA IDA: Inferred from direct assay	12796785	MGI
involved in positive regulation of circadian sleep/wake cycle, wakefulness	IMP IMP: Inferred from mutant phenotype	23716671	MGI
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	23143522	MGI
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	17582332	MGI
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	23143522	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	21356198	MGI
involved in positive regulation of synaptic vesicle clustering	IDA IDA: Inferred from direct assay	15620359	MGI
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	19628693	MGI
involved in positive regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	19628693	MGI
involved in postsynaptic density protein 95 clustering	IDA IDA: Inferred from direct assay	12796785	MGI
involved in postsynaptic membrane assembly	IDA IDA: Inferred from direct assay	12796785	MGI
involved in postsynaptic specialization assembly	IDA IDA: Inferred from direct assay	15620359	MGI
involved in postsynaptic specialization assembly	IMP IMP: Inferred from mutant phenotype	15620359	MGI
involved in presynaptic membrane assembly	IDA IDA: Inferred from direct assay	10892652	MGI
involved in protein localization to synapse	IDA IDA: Inferred from direct assay	15620359	MGI
involved in receptor localization to synapse	IDA IDA: Inferred from direct assay	12796785	MGI
involved in regulation of NMDA receptor activity	IDA IDA: Inferred from direct assay	17582332	MGI
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	23143522	MGI
involved in regulation of neuron differentiation	IDA IDA: Inferred from direct assay	10892652	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	32324534	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	32324534	MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process	IGI IGI: Inferred from genetic interaction	16982420	MGI
acts upstream of synapse assembly	IDA IDA: Inferred from direct assay	21356198	MGI
involved in synapse assembly	IDA IDA: Inferred from direct assay	10892652	MGI
acts upstream of or within synapse organization	IGI IGI: Inferred from genetic interaction	21788371	MGI
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	12796785	MGI
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	12796785	MGI
involved in synaptic vesicle clustering	IDA IDA: Inferred from direct assay	10892652	MGI
involved in synaptic vesicle targeting	IMP IMP: Inferred from mutant phenotype	10892652	MGI
involved in terminal button organization	IMP IMP: Inferred from mutant phenotype	19628693	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	23791195	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	20573900	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15620359	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15620359	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	10892652	MGI
part of receptor complex	IDA IDA: Inferred from direct assay	12796785	MGI
located in synapse	IDA IDA: Inferred from direct assay	12202822	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuroligin-1

Nlgn1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Nlgn1	Q99K10	PTPRT	Homo sapiens	O14522	Anti Tag CoIP	19816407
Cross	Nlgn1	Q99K10	Kalrn	Rattus norvegicus	P97924-5	Anti Tag CoIP	31801062

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Nlgn1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74704	Neuroligin-1/NLGN1 Protein, Mouse (HEK293, His)	Q99K10-1 (Q46-S697)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09339	NLGN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlgn1	NCBI	NCBI:22871

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