EFNB2 - ephrin B2 Gene

Homo sapiens

Also known as HTKL; EPLG5; Htk-L; LERK5; ephrin-B2

Gene ID: 1948 | Gene type: protein coding

About EFNB2

Cytogenetic location: 13q33.3 Genomic coordinates (GRCh38): 13:106,489,745-106,535,662 (from NCBI)

This gene has 2 transcripts (splice variants), 221 orthologues and 7 paralogues. Ubiquitous expression in lung (RPKM 8.5), colon (RPKM 7.4) and 23 other tissues.

Summary

This gene encodes a member of the ephrin (EPH) family. The Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EphB4 and EphA3 receptors. [provided by RefSeq, Jul 2008]

EFNB2 Products(4)

mRNA	Protein	Name
NM_001372056.1	NP_001358985.1	ephrin-B2 isoform 2
NM_001372057.1	NP_001358986.1	ephrin-B2 isoform 3
NM_001372058.1	NP_001358987.1	ephrin-B2 isoform 4 precursor
NM_004093.4	NP_004084.1	ephrin-B2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	16867992	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12606549	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	12734395	GOA
involved in cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	12734395	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	12734395	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	10066262	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	26268439	GOA
involved in regulation of chemotaxis	IDA IDA: Inferred from direct assay	12734395	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	17251577	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EFNB2 Protein Structure

Ephrin

0
100
200
300
333 a.a.

Protein Preferred Names

Protein Names

ephrin-B2

HTK ligand

EFNB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EFNB2	P52799	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Cross	EFNB2	P52799	G	Nipah virus	Q9IH62	SPR	18488039
Intra	EFNB2	P52799	EPHB4	Homo sapiens	P54760	SPR	26481148
Intra	EFNB2	P52799	EPHB4	Homo sapiens	P54760	Anti Tag CoIP	33961781
Intra	EFNB2	P52799	EPHB4	Homo sapiens	P54760	Anti Tag CoIP	28514442
Intra	EFNB2	P52799	NCK2	Homo sapiens	O43639	CD	12606549
Intra	EFNB2	P52799	NCK2	Homo sapiens	O43639	NMR	15764601
Intra	EFNB2	P52799	NCK2	Homo sapiens	O43639	NMR	12606549
Cross	EFNB2	P52799	G	Hendra virus	O89343	X-Ray Diffraction	18488039
Cross	EFNB2	P52799	G	Hendra virus	O89343	GMS	18488039

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EFNB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70377	Ephrin-B2/EFNB2 Protein, Human (HEK293, His)	P52799 (I28-A229)	≥95%
HY-P73015	Ephrin-B2/EFNB2 Protein, Human (HEK293)	P52799 (I28-A229)	≥95%
HY-P73016	Ephrin-B2/EFNB2 Protein, Human (HEK293, His-Fc)	P52799 (I28-A229)	≥95%
HY-P77645	Ephrin-B2/EFNB2 Protein, Human (HEK293, Fc)	P52799 (I28-A229)	≥95%

Related Diseases

Diseases

Alias

Nipah Virus Encephalitis

Equine Morbillivirus

Pyogenic Granuloma

Lobular Capillary Hemangioma	Granuloma Pyogenic
Granuloma Pyogenicum	Granuloma Telangiectaticum Of Skin
Pyogenic Granuloma Of Skin	Lobular Capillary Haemangioma Of Skin

Lymphatic Malformation 12

Central Conducting Lymphatic Anomaly	LMPHM12
Ccla	Lymphatic Malformation-7
Doid:0081030

Kaposi Sarcoma

Kaposi'S Sarcoma	Kaposi Sarcoma, Susceptibility To
Kaposi'S Sarcoma Of Lung	Kaposi'S Sarcoma Of Palate
Kaposi'S Sarcoma Of Soft Tissue	Kaposi'S Sarcoma-Associated Herpesvirus
Multiple Idiopathic Pigmented Hemangiosarcoma	Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To
African Lymphadenopathic Kaposi'S Sarcoma	Anal Kaposi'S Sarcoma
Cardiac Kaposi'S Sarcoma	Central Nervous System Kaposi'S Sarcoma
Conjunctival Kaposi'S Sarcoma	Corneal Kaposi'S Sarcoma
Cutaneous Kaposi'S Sarcoma	Esophageal Kaposi'S Sarcoma
Gallbladder Kaposi'S Sarcoma	Gastric Kaposi'S Sarcoma
Intestinal Kaposi'S Sarcoma	Kaposi'S Sarcoma Of Anus
Kaposi'S Sarcoma Of Central Nervous System	Kaposi'S Sarcoma Of Conjunctiva
Kaposi'S Sarcoma Of Cornea	Kaposi'S Sarcoma Of Esophagus
Kaposi'S Sarcoma Of Gastrointestinal Sites	Kaposi'S Sarcoma Of Heart
Kaposi'S Sarcoma Of Lymph Nodes	Kaposi'S Sarcoma Of Penis
Kaposi'S Sarcoma Of Skin	Kaposi'S Sarcoma Of Soft Tissues
Kaposi'S Sarcoma Of The Cns	Kaposi'S Sarcoma Of The Gallbladder
Kaposi'S Sarcoma Of The Prostate	Kaposi'S Sarcoma, Lung
Kaposi'S Sarcoma, Skin	Lymph Node Kaposi'S Sarcoma
Lymphadenopathic Kaposi'S Sarcoma	Palate Kaposi'S Sarcoma
Penis Kaposi'S Sarcoma	Prostate Kaposi'S Sarcoma
Pulmonary Kaposi'S Sarcoma	Soft Tissue Kaposi'S Sarcoma
Hhv8	Human Herpesvirus 8
Kshv	Kaposi Sarcoma Herpesvirus
Mediterranean Kaposi Sarcoma	Non Aids Related Kaposi Sarcoma
Sarcoma, Kaposi	Sarcoma, Kaposi, Susceptibility To
Non-Aids-Related Kaposi Sarcoma	Angiolymphoid Hyperplasia
Angiofollicular Ganglionic Hyperplasia	Multi-Centric Castleman'S Disease

Craniofrontonasal Syndrome

Craniofrontonasal Dysplasia	CFNS
Cfnd	Craniofrontonasal Dysostosis
Craniofrontonasal Dystosis	Dysplasia, Craniofrontonasal

Arteriovenous Malformation

Arteriovenous Malformations	Arteriovenous Hemangioma
Cirsoid Aneurysm	Racemose Aneurysm
Racemose Angioma	Racemose Hemangioma
Congenital Arteriovenous Malformation

Chylothorax, Congenital

Congenital Chylothorax

Hydrothorax, Congenital

Ectopic Thymus

Lymphedema-Distichiasis Syndrome

Lymphedema With Distichiasis	Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus
LPHDST	Distichiasis-Lymphedema Syndrome
Lymphedema Distichiasis Syndrome	Hereditary Lymphedema-Distichiasis Syndrome
Lymphedema Distichiasis

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Hereditary Lymphedema

Milroy Disease

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Inner Ear Disease

Labyrinthine Dysfunction	Diseases Of Inner Ear
Labyrinthine Disease	Abnormality Of The Inner Ear
Labyrinth Diseases	Labyrinthine Disorder
Nonfunctioning Labyrinth	Labyrinthine Loss Of Function
Labyrinthine Syndrome	Labyrinthine Disorder Nos

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment	Ncrna Disease
Non-Syndromic Congenital Retinal Non-Attachment	Pfvs
Phpv	Persistent Fetal Vasculature Syndrome

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation	Intracranial Arteriovenous Malformation
Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To	Intracranial Arteriovenous Malformations
Bavm	Cerebral Arteriovenous Malformations
Intracranial Hemorrhage In Brain Cerebrovascular Malformations	Arteriovenous Malformation Of The Brain, Somatic
Intracranial Avm	Arteriovenous Malformations Cerebral

Hereditary Hemorrhagic Telangiectasia

Rendu-Osler-Weber Disease	Hht
Osler-Weber-Rendu Disease	Telangiectasia, Hereditary Hemorrhagic
Osler Hemorrhagic Telangiectasia Syndrome	Orw Disease
Osler Weber Rendu Syndrome	Osler-Rendu-Weber Disease
Osler-Weber-Rendu Syndrome	Rendu-Osler Disease
Telangiectasia Hereditary Hemorrhagic	Telangiectasia Hemorrhagic, Hereditary
Hht - [Hereditary Haemorrhagic Telangiectasia]	Osler Haemorrhagic Telangiectasia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04198	EFNB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EFNB2	VGNC	VGNC:28360
Rattus norvegicus	EFNB2	RGD	RGD:1309497
Mus musculus	EFNB2	MGD	MGI:105097
Macaca mulatta	EFNB2	VGNC	VGNC:72170
Canis familiaris	EFNB2	VGNC	VGNC:40229
Felis catus	EFNB2	VGNC	VGNC:61750
Others	EFNB2	NCBI

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