2. Gene
  3. METTL15 - methyltransferase like 15 Gene

METTL15 - methyltransferase like 15 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as METT5D1

Gene ID: 196074 | Gene type: protein coding

About METTL15

Cytogenetic location: 11p14.1 Genomic coordinates (GRCh38): 11:28,108,388-28,532,475 (from NCBI)

This gene has 12 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 2.9), adrenal (RPKM 2.8) and 25 other tissues.

Summary

Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be located in mitochondrial matrix. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

METTL15 Products(3)

mRNA Protein Name
NM_001113528.2 NP_001107000.1 12S rRNA N4-methylcytidine (m4C) methyltransferase isoform 1
NM_001297775.2 NP_001284704.1 12S rRNA N4-methylcytidine (m4C) methyltransferase isoform 3
NM_152636.3 NP_689849.2 12S rRNA N4-methylcytidine (m4C) methyltransferase isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables rRNA (cytosine-N4-)-methyltransferase activity IDA
IDA: Inferred from direct assay
31665743 GOA
Biological Process GO Annotation Evidence Reference Source
involved in rRNA base methylation IDA
IDA: Inferred from direct assay
31665743 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
31665743 GOA
is active in mitochondrion IDA
IDA: Inferred from direct assay
32371392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL15 Protein Structure

Methyltransf_5

Methyltransf_5: MraW methylase family (71 - 405)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
Protein Preferred Names Protein Names

12S rRNA N4-methylcytidine (m4C) methyltransferase

12S rRNA m4C methyltransferase

METTL15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
METTL15 A6NJ78 MVB12B Homo sapiens Q9H7P6
Anti Tag CoIP
33961781
Intra
METTL15 A6NJ78 MVB12B Homo sapiens Q9H7P6
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08356 METTL15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris METTL15 VGNC VGNC:52267
Bos taurus METTL15 VGNC VGNC:54885
Rattus norvegicus METTL15 RGD RGD:1304978
Felis catus METTL15 VGNC VGNC:82018
Mus musculus METTL15 MGD MGI:1924144
Macaca mulatta METTL15 VGNC VGNC:101350