VSTM4 - V-set and transmembrane domain containing 4 Gene

Homo sapiens

Also known as C10orf72

Gene ID: 196740 | Gene type: protein coding

About VSTM4

This gene has 3 transcripts (splice variants), 264 orthologues and 5 paralogues. Broad expression in adrenal (RPKM 18.4), ovary (RPKM 14.7) and 19 other tissues.

Summary

Predicted to act upstream of or within several processes, including endothelial cell migration; retina blood vessel maintenance; and vasculature development. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

VSTM4 Products(2)

mRNA	Protein	Name
NM_001031746.5	NP_001026916.2	V-set and transmembrane domain-containing protein 4 isoform 1 precursor
NM_144984.4	NP_659421.1	V-set and transmembrane domain-containing protein 4 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSTM4 Protein Structure

V-set

0
100
200
300
320 a.a.

Protein Preferred Names

Protein Names

V-set and transmembrane domain-containing protein 4

VSTM4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VSTM4	Q8IW00	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	VSTM4	Q8IW00	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	VSTM4	Q8IW00	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	VSTM4	Q8IW00	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	VSTM4	Q8IW00	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	VSTM4	Q8IW00	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	VSTM4	Q8IW00	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	VSTM4	Q8IW00	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	VSTM4	Q8IW00	TGM1	Homo sapiens	P22735	Y2H Array	32296183
Intra	VSTM4	Q8IW00	TGM1	Homo sapiens	P22735	Y2H Prey Pooling	32296183
Intra	VSTM4	Q8IW00	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	VSTM4	Q8IW00	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	VSTM4	Q8IW00	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	VSTM4	Q8IW00	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	VSTM4	Q8IW00	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	VSTM4	Q8IW00	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	VSTM4	Q8IW00	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	VSTM4	Q8IW00	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	VSTM4	Q8IW00	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	VSTM4	Q8IW00	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Jackson-Weiss Syndrome

JWS	Craniosynostosis, Midfacial Hypoplasia, And Foot Abnormalities
Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities Syndrome	Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15717	VSTM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VSTM4	VGNC	VGNC:53017
Mus musculus	VSTM4	MGD	MGI:2444633
Rattus norvegicus	VSTM4	RGD	RGD:1310423
Felis catus	VSTM4	VGNC	VGNC:66984
Macaca mulatta	VSTM4	VGNC	VGNC:79615
Bos taurus	VSTM4	VGNC	VGNC:54511

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