NLRC3 - NLR family CARD domain containing 3 Gene

Homo sapiens

Also known as NOD3; CLR16.2

Gene ID: 197358 | Gene type: protein coding

About NLRC3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,539,033-3,577,403 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 6.9), spleen (RPKM 4.9) and 23 other tissues.

Summary

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

NLRC3 Products(1)

mRNA	Protein	Name
NM_178844.4	NP_849172.2	NLR family CARD domain-containing protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24560620	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell activation	IEP IEP: Inferred from expression pattern	15705585	GOA
involved in canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15705585	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15705585	GOA
involved in negative regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	25277106	GOA
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22863753	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	25277106	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	22863753	GOA
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	22863753	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	25277106	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	22863753	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	22863753	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15705585	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	24560620	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLRC3 Protein Structure

NACHT

LRR_6

0
200
400
600
800
1036 a.a.

Protein Preferred Names

Protein Names

NLR family CARD domain-containing protein 3

CARD15-like protein

Related Diseases

Diseases

Alias

Cicatricial Entropion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09346	NLRC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NLRC3	VGNC	VGNC:43843
Macaca mulatta	NLRC3	VGNC	VGNC:75282
Felis catus	NLRC3	VGNC	VGNC:63826
Rattus norvegicus	NLRC3	RGD	RGD:1304902
Mus musculus	NLRC3	MGD	MGI:2444070
Bos taurus	NLRC3	VGNC	VGNC:32112

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