2. Gene
  3. EIF4G2 - eukaryotic translation initiation factor 4 gamma 2 Gene

EIF4G2 - eukaryotic translation initiation factor 4 gamma 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P97; AAG1; DAP5; NAT1

Gene ID: 1982 | Gene type: protein coding

About EIF4G2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:10,797,046-10,808,926 (from NCBI)

This gene has 31 transcripts (splice variants), 280 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 207.4), placenta (RPKM 201.0) and 25 other tissues.

Summary

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

EIF4G2 Products(3)

mRNA Protein Name
NM_001042559.3 NP_001036024.3 eukaryotic translation initiation factor 4 gamma 2 isoform 2
NM_001172705.1 NP_001166176.1 eukaryotic translation initiation factor 4 gamma 2 isoform 1
NM_001418.4 NP_001409.3 eukaryotic translation initiation factor 4 gamma 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16166382 GOA
enables translation factor activity, RNA binding IDA
IDA: Inferred from direct assay
16289705 GOA
enables translation initiation factor activity IDA
IDA: Inferred from direct assay
11943866 GOA
Biological Process GO Annotation Evidence Reference Source
involved in macromolecule biosynthetic process IGI
IGI: Inferred from genetic interaction
18426977 GOA
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
18426977 GOA
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
18426977 GOA
involved in regulation of translational initiation IDA
IDA: Inferred from direct assay
11943866 GOA
Cellular Component GO Annotation Evidence Reference Source
part of eukaryotic translation initiation factor 4F complex IDA
IDA: Inferred from direct assay
11943866 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4G2 Protein Structure

MIF4G

MIF4G: MIF4G domain (79 - 307)

MA3

MA3: MA3 domain (548 - 655)

W2

W2: eIF4-gamma/eIF5/eIF2-epsilon (825 - 905)

  • 0
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  • 800
  • 907 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4 gamma 2

DAP-5

EIF4G2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
EIF4G2 P78344 HSPB1 Homo sapiens P04792
Anti Bait CoIP
25277244
Intra
EIF4G2 P78344 EIF2S2 Homo sapiens P20042
Anti Bait CoIP
16932749
Intra
EIF4G2 P78344 EIF4A1 Homo sapiens P60842
NMR
16166382
Cross
EIF4G2 P78344 P29991-PRO_0000308465 Dengue virus type 2 P29991-PRO_0000308465
Y2H
21911577
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mouth Disease

Mouth Diseases

Mouth Disorders
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04282 EIF4G2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EIF4G2 MGD MGI:109207
Rattus norvegicus EIF4G2 RGD RGD:1305294
Bos taurus EIF4G2 VGNC VGNC:28416
Macaca mulatta EIF4G2 VGNC VGNC:72196
Felis catus EIF4G2 VGNC VGNC:61795
Canis familiaris EIF4G2 VGNC VGNC:52256