EIF5 - eukaryotic translation initiation factor 5 Gene

Homo sapiens

Also known as EIF-5; EIF-5A

Gene ID: 1983 | Gene type: protein coding

About EIF5

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:103,334,237-103,345,025 (from NCBI)

This gene has 21 transcripts (splice variants) and 265 orthologues. Ubiquitous expression in bone marrow (RPKM 60.5), thyroid (RPKM 44.5) and 25 other tissues.

Summary

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]

EIF5 Products(2)

mRNA	Protein	Name
NM_001969.5	NP_001960.2	eukaryotic translation initiation factor 5
NM_183004.5	NP_892116.2	eukaryotic translation initiation factor 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21745818	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of translational initiation	IDA IDA: Inferred from direct assay	22156057	GOA
involved in ribosome assembly	IDA IDA: Inferred from direct assay	10659855	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12426392	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	12426392	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF5 Protein Structure

eIF-5_eIF-2B

0
100
200
300
400
431 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 5

Recombinant EIF5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75255	EIF5 Protein, Human (His)	P55010 (M1-D150)	≥95%
HY-P700566	EIF5 Protein, Human (His-SUMO)	P55010 (M1-I431)	≥95%

Related Diseases

Diseases

Alias

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111522	RK-9123016	Inhibitor	99.02%	Unkown
HY-RS04285	EIF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04286	EIF5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04287	EIF5A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04288	EIF5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121722	Deoxyhypusine		/	Unkown
HY-122039	Hypusine dihydrochloride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EIF5	VGNC	VGNC:28418
Felis catus	EIF5	VGNC	VGNC:61797
Rattus norvegicus	EIF5	RGD	RGD:619861
Macaca mulatta	EIF5	VGNC	VGNC:72197
Canis familiaris	EIF5	VGNC	VGNC:40292
Mus musculus	EIF5	MGD	MGI:95309
Others	EIF5	NCBI

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