DUSP12 - dual specificity phosphatase 12 Gene

Homo sapiens

Also known as YVH1; DUSP1

Gene ID: 11266 | Gene type: protein coding

About DUSP12

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,749,786-161,757,238 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 30 paralogues. Ubiquitous expression in bone marrow (RPKM 12.0), lymph node (RPKM 7.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine Phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

DUSP12 Products(1)

mRNA	Protein	Name
NM_007240.3	NP_009171.1	dual specificity protein phosphatase 12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase activity	IDA IDA: Inferred from direct assay	10446167	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	10446167	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in dephosphorylation	IDA IDA: Inferred from direct assay	10446167	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10446167	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10446167	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP12 Protein Structure

DSPc

0
100
200
300
340 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 12

YVH1 protein-tyrosine phosphatase ortholog

DUSP12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DUSP12	Q9UNI6	PPP2R3B	Homo sapiens	Q9Y5P8	Validated Y2H	25416956
Intra	DUSP12	Q9UNI6	PPP2R3B	Homo sapiens	Q9Y5P8	Y2H Prey Pooling	25416956
Intra	DUSP12	Q9UNI6	EIF5	Homo sapiens	P55010	Y2H Prey Pooling	25416956
Intra	DUSP12	Q9UNI6	EIF5	Homo sapiens	P55010	Y2H Array	25416956
Intra	DUSP12	Q9UNI6	M6PR	Homo sapiens	P20645	Y2H Prey Pooling	32296183
Intra	DUSP12	Q9UNI6	M6PR	Homo sapiens	P20645	Y2H Array	32296183
Intra	DUSP12	Q9UNI6	USO1	Homo sapiens	O60763	Y2H Prey Pooling	25416956
Intra	DUSP12	Q9UNI6	RABAC1	Homo sapiens	Q9UI14	Validated Y2H	25416956
Intra	DUSP12	Q9UNI6	RABAC1	Homo sapiens	Q9UI14	Y2H Prey Pooling	32296183
Intra	DUSP12	Q9UNI6	RABAC1	Homo sapiens	Q9UI14	Y2H Array	25416956
Intra	DUSP12	Q9UNI6	RABAC1	Homo sapiens	Q9UI14	Y2H Array	32296183
Intra	DUSP12	Q9UNI6	HSPB8	Homo sapiens	Q9UJY1	Validated Y2H	25416956
Intra	DUSP12	Q9UNI6	CALCOCO2	Homo sapiens	Q13137	Y2H Array	31515488
Intra	DUSP12	Q9UNI6	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	DUSP12	Q9UNI6	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	DUSP12	Q9UNI6	CALCOCO2	Homo sapiens	Q13137	Y2H	21516116
Intra	DUSP12	Q9UNI6	CCNH	Homo sapiens	P51946	Y2H Array	31515488
Intra	DUSP12	Q9UNI6	CCNH	Homo sapiens	P51946	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gastrointestinal Neuroendocrine Benign Tumor

Gastric Neuroendocrine Neoplasm

Gastric Neuroendocrine Tumor	Neuroendocrine Tumor Of The Stomach
Neuroendocrine Tumor Of Stomach	Gnet
Gastric Net	Net Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04053	DUSP12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DUSP12	VGNC	VGNC:40128
Rattus norvegicus	DUSP12	RGD	RGD:68375
Mus musculus	DUSP12	MGD	MGI:1890614
Felis catus	DUSP12	VGNC	VGNC:61661
Bos taurus	DUSP12	VGNC	VGNC:28251

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