2. Gene
  3. FBXO15 - F-box protein 15 Gene

FBXO15 - F-box protein 15 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FBX15

Gene ID: 201456 | Gene type: protein coding

About FBXO15

Cytogenetic location: 18q22.3 Genomic coordinates (GRCh38): 18:74,073,368-74,147,834 (from NCBI)

This gene has 14 transcripts (splice variants), 239 orthologues and 1 paralogue. Biased expression in testis (RPKM 2.7), kidney (RPKM 0.4) and 3 other tissues.

Summary

Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXO15 Products(2)

mRNA Protein Name
NM_001142958.2 NP_001136430.1 F-box only protein 15 isoform 2
NM_152676.3 NP_689889.1 F-box only protein 15 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO15 Protein Structure

F-box-like

F-box-like: F-box-like (77 - 117)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
Protein Preferred Names Protein Names

F-box only protein 15

FBXO15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FBXO15 Q8NCQ5 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
FBXO15 Q8NCQ5 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
FBXO15 Q8NCQ5 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04796 FBXO15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FBXO15 RGD RGD:1310628
Bos taurus FBXO15 VGNC VGNC:28893
Macaca mulatta FBXO15 VGNC VGNC:72504
Mus musculus FBXO15 MGD MGI:1354755
Felis catus FBXO15 VGNC VGNC:62177
Canis familiaris FBXO15 VGNC VGNC:40763