HACD2 - 3-hydroxyacyl-CoA dehydratase 2 Gene

Homo sapiens

Also known as PTPLB

Gene ID: 201562 | Gene type: protein coding

About HACD2

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:123,491,554-123,585,053 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 34.0), prostate (RPKM 10.4) and 24 other tissues.

Summary

The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. [provided by RefSeq, Jul 2016]

HACD2 Products(5)

mRNA	Protein	Name
NM_001329783.2	NP_001316712.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform a
NM_001329784.2	NP_001316713.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform c
NM_001329786.2	NP_001316715.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform d
NM_001329787.2	NP_001316716.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform d
NM_198402.5	NP_940684.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-hydroxyacyl-CoA dehydratase activity	EXP EXP: Inferred from Experiment	18554506	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	18554506	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15024066	GOA
NOT enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	15024066	GOA
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	IDA IDA: Inferred from direct assay	18554506	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid elongation	IDA IDA: Inferred from direct assay	18554506	GOA
involved in sphingolipid biosynthetic process	IGI IGI: Inferred from genetic interaction	18554506	GOA
involved in very long-chain fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	18554506	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15024066	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HACD2 Protein Structure

PTPLA

0
100
200
254 a.a.

Protein Preferred Names

Protein Names

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b

HACD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HACD2	Q6Y1H2	IL10RA	Homo sapiens	Q13651	Y2H Array	32296183
Intra	HACD2	Q6Y1H2	IL10RA	Homo sapiens	Q13651	Y2H Prey Pooling	32296183
Intra	HACD2	Q6Y1H2	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	HACD2	Q6Y1H2	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	HACD2	Q6Y1H2	TECR	Homo sapiens	Q9NZ01	Validated Y2H	32296183
Intra	HACD2	Q6Y1H2	TECR	Homo sapiens	Q9NZ01	Y2H Array	32296183
Intra	HACD2	Q6Y1H2	TECR	Homo sapiens	Q9NZ01	Y2H Prey Pooling	32296183
Intra	HACD2	Q6Y1H2	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	HACD2	Q6Y1H2	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	HACD2	Q6Y1H2	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	HACD2	Q6Y1H2	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	HACD2	Q6Y1H2	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	HACD2	Q6Y1H2	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	HACD2	Q6Y1H2	BCAP31	Homo sapiens	P51572	Anti Tag CoIP	15024066
Intra	HACD2	Q6Y1H2	BCAP31	Homo sapiens	P51572	IF	15024066
Intra	HACD2	Q6Y1H2	BCAP31	Homo sapiens	P51572	Ub Reconstruction	15024066

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Unilateral Focal Polymicrogyria

Spinocerebellar Ataxia 34

Erythrokeratodermia With Ataxia	Spinocerebellar Ataxia Type 34
SCA34	Erythrokeratodermia - Ataxia
Giroux Barbeau Syndrome	Spinocerebellar Ataxia And Erythrokeratodermia
Erythrokeratodermia Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05985	HACD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HACD2	VGNC	VGNC:102753
Rattus norvegicus	HACD2	RGD	RGD:1306337
Mus musculus	HACD2	MGD	MGI:1918007
Bos taurus	HACD2	VGNC	VGNC:50252
Macaca mulatta	HACD2	VGNC	VGNC:73382
Canis familiaris	HACD2	VGNC	VGNC:53075

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