TECR - trans-2,3-enoyl-CoA reductase Gene

Homo sapiens

Also known as SC2; TER; GPSN2; MRT14

Gene ID: 9524 | Gene type: protein coding

About TECR

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,527,726-14,565,980 (from NCBI)

This gene has 26 transcripts (splice variants), 268 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 95.3), skin (RPKM 93.5) and 25 other tissues.

Summary

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]

TECR Products(2)

mRNA	Protein	Name
NM_001321170.1	NP_001308099.1	very-long-chain enoyl-CoA reductase isoform 2
NM_138501.6	NP_612510.1	very-long-chain enoyl-CoA reductase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables very-long-chain enoyl-CoA reductase activity	IDA IDA: Inferred from direct assay	12482854	GOA
enables very-long-chain enoyl-CoA reductase activity	IMP IMP: Inferred from mutant phenotype	24220030	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid elongation	IDA IDA: Inferred from direct assay	12482854	GOA
involved in sphingolipid metabolic process	IMP IMP: Inferred from mutant phenotype	25049234	GOA
involved in very long-chain fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	12482854	GOA
involved in very long-chain fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	24220030	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24220030	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	12482854	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TECR Protein Structure

Steroid_dh

0
100
200
308 a.a.

Protein Preferred Names

Protein Names

very-long-chain enoyl-CoA reductase

epididymis secretory sperm binding protein

TECR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TECR	Q9NZ01	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	TECR	Q9NZ01	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	TECR	Q9NZ01	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	TFAM	Homo sapiens	Q00059	Y2H Array	32296183
Intra	TECR	Q9NZ01	TFAM	Homo sapiens	Q00059	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	TECR	Q9NZ01	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
Intra	TECR	Q9NZ01	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TECR	Q9NZ01	HACD1	Homo sapiens	B0YJ81	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	HACD1	Homo sapiens	B0YJ81	Y2H Array	32296183
Intra	TECR	Q9NZ01	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	TECR	Q9NZ01	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Array	32296183
Intra	TECR	Q9NZ01	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	TECR	Q9NZ01	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	TECR	Q9NZ01	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TECR	Q9NZ01	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TECR	Q9NZ01	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	TECR	Q9NZ01	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	TECR	Q9NZ01	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	TECR	Q9NZ01	STING1	Homo sapiens	Q86WV6	Y2H Array	32296183
Intra	TECR	Q9NZ01	STING1	Homo sapiens	Q86WV6	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	TECR	Q9NZ01	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	TECR	Q9NZ01	HACD2	Homo sapiens	Q6Y1H2	Crosslink	30021884
Intra	TECR	Q9NZ01	HACD2	Homo sapiens	Q6Y1H2	Y2H Prey Pooling	25416956
Intra	TECR	Q9NZ01	HACD2	Homo sapiens	Q6Y1H2	Y2H Array	25416956
Intra	TECR	Q9NZ01	HACD2	Homo sapiens	Q6Y1H2	Validated Y2H	25416956
Intra	TECR	Q9NZ01	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	TECR	Q9NZ01	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TECR	Q9NZ01	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TECR	Q9NZ01	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TECR	Q9NZ01	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 14

MRT14	Mental Retardation, Autosomal Recessive 14
Autosomal Recessive Intellectual Developmental Disorder 14	Mental Retardation, Autosomal Recessive, Type 14

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Seborrheic Infantile Dermatitis

Cradle Cap	Infantile Seborrhoeic Dermatitis
Seborrhoea Capitis	Seborrhoeic Dermatitis Of Scalp
Seborrhoeic Eczema Of Scalp	Complement 5 Dysfunction
Generalized Seborrheic Dermatitis Of Infants	Infantile Seborrheic Dermatitis
Pityriasis Capitis	Seborrhea Capitis
Seborrhea Sicca	Dandruff
Complement Component 5 Deficiency	Seborrheic Dermatitis
Seborrheic Dermatitis Of Scalp	Scurfiness Of Scalp
Seborrheic Dermatitis Of Infancy	Infantile Seborrhoeic Eczema
Neonatal Seborrhoeic Dermatitis	Infantile Seborrhoeic Dermatitis Of The Scalp

Cataract 24

CTRCT24	Cataract 24, Anterior Polar
Cataract, Anterior Polar, 2	Ctaa2
Anterior Polar Cataract 2	Early-Onset Anterior Polar Cataract
Early-Onset Anterior Subcapsular Cataract	Anterior Polar Cataract 24
Cataract Anterior Polar	Cataract, Anterior Polar-2
Cataract, Anterior Polar

Tongue Carcinoma

Tongue Cancer	Malignant Neoplasm Of Tongue
Tongue Neoplasms	Tongue Neoplasm

Oral Mucosa Leukoplakia

Leukoplakia, Oral

Leukoplakia Of Buccal Mucosa

Spindle Cell Hemangioma

Sch	Spindle Cell Hemangioendothelioma

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14349	TECR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TECR	VGNC	VGNC:80732
Macaca mulatta	TECR	VGNC	VGNC:103877
Canis familiaris	TECR	VGNC	VGNC:47234
Rattus norvegicus	TECR	RGD	RGD:620376
Bos taurus	TECR	VGNC	VGNC:35730
Mus musculus	TECR	MGD	MGI:1915408

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