STT3B - STT3 oligosaccharyltransferase complex catalytic subunit B Gene

Homo sapiens

Also known as SIMP; CDG1X; STT3-B

Gene ID: 201595 | Gene type: protein coding

About STT3B

Cytogenetic location: 3p23 Genomic coordinates (GRCh38): 3:31,532,925-31,637,616 (from NCBI)

This gene has 7 transcripts (splice variants), 274 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 42.8), thyroid (RPKM 37.3) and 25 other tissues.

Summary

The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]

STT3B Products(1)

mRNA	Protein	Name
NM_178862.3	NP_849193.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IMP IMP: Inferred from mutant phenotype	19167329	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19167329	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	22607976	GOA
involved in co-translational protein modification	IMP IMP: Inferred from mutant phenotype	19167329	GOA
involved in glycoprotein catabolic process	IMP IMP: Inferred from mutant phenotype	22607976	GOA
involved in post-translational protein modification	IMP IMP: Inferred from mutant phenotype	19167329	GOA
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	31831667	GOA
involved in protein N-linked glycosylation	IMP IMP: Inferred from mutant phenotype	22467853	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	19167329	GOA
involved in response to unfolded protein	IMP IMP: Inferred from mutant phenotype	19167329	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	22467853	GOA
part of oligosaccharyltransferase complex	IPI IPI: Inferred from physical interaction	31831667	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	28246125	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STT3B Protein Structure

STT3

0
200
400
600
826 a.a.

Protein Preferred Names

Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

STT3, subunit of the oligosaccharyltransferase complex, homolog B

STT3B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STT3B	Q8TCJ2	RPN1	Homo sapiens	P04843	Crosslink	30021884
Intra	STT3B	Q8TCJ2	RPN1	Homo sapiens	P04843	Anti Tag CoIP	35271311
Intra	STT3B	Q8TCJ2	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	STT3B	Q8TCJ2	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation, Type Ix

CDG1X	Cdg Ix
Cdgix	Congenital Disorder Of Glycosylation 1x
Stt3b-Cdg	Cdg-Ix
Congenital Disorder Of Glycosylation Type Ix	Congenital Disorder Of Glycosylation Ix
Cdg Syndrome Type Ix	Carbohydrate Deficient Glycoprotein Syndrome Type Ix
Congenital Disorder Of Glycosylation Type 1x	Glycosylation, Congenital Disorder Of, Type Ix

Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

XMEN	X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
Cid Due To Magt1 Deficiency	Combined Immunodeficiency Due To Magt1 Deficiency
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An	X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii	CDG2E
Congenital Disorder Of Glycosylation Type Iie	IMD47
Cdg2s	Cdg Iis
Cdgiis	Immunodeficiency And Hepatopathy With Or Without Neurologic Features
Congenital Disorder Of Glycosylation, Type Ii	CDG1I
Congenital Disorder Of Glycosylation, Type Iie	Cdg Iie
Congenital Disorder Of Glycosylation Type 2e	Congenital Disorder Of Glycosylation, Type Iis
Cdg Ii	Cdgii
Cdgiie	Carbohydrate Deficient Glycoprotein Syndrome Type Iie
Cdg Syndrome Type Iie	Congenital Disorder Of Glycosylation Ii
Congenital Disorder Of Glycosylation 1i	Cdg-Iie
Alg2-Cdg	Cdg-Ii
Glycosylation, Congenital Disorder Of, Type Ii	Cdgiide
Congenital Disorder Of Glycosylation Type Iis	Cog7-Cdg
Cdg Syndrome Type Ii	Carbohydrate Deficient Glycoprotein Syndrome Type Ii
Congenital Disorder Of Glycosylation Type 1i	Mannosyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2e	Congenital Disorder Of Glycosylation 2s
Congenital Disorders Of Glycosylation Type Ii	Glycosylation, Congenital Disorder Of, Type Iie
Immunodeficiency, Type 47	Congenital Disorder Of Glycosylation Type 2a

Louping Ill

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117383	NGI-1	Inhibitor	99.95%	Unkown
HY-RS13971	STT3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STT3B	MGD	MGI:1915542
Felis catus	STT3B	VGNC	VGNC:65804
Bos taurus	STT3B	VGNC	VGNC:35428
Macaca mulatta	STT3B	VGNC	VGNC:78245
Canis familiaris	STT3B	VGNC	VGNC:52904
Rattus norvegicus	STT3B	RGD	RGD:1311563

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