RANBP3L - RAN binding protein 3 like Gene

Homo sapiens

Gene ID: 202151 | Gene type: protein coding

About RANBP3L

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:36,246,913-36,301,902 (from NCBI)

This gene has 4 transcripts (splice variants), 141 orthologues and 10 paralogues. Biased expression in brain (RPKM 8.6), kidney (RPKM 8.4) and 11 other tissues.

Summary

Enables SMAD binding activity. Predicted to be involved in several processes, including mesenchymal cell differentiation involved in bone development; negative regulation of osteoblast differentiation; and positive regulation of myoblast differentiation. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RANBP3L Products(10)

mRNA	Protein	Name
NM_001161429.3	NP_001154901.1	ran-binding protein 3-like isoform 1
NM_001323273.2	NP_001310202.1	ran-binding protein 3-like isoform 3
NM_001323274.2	NP_001310203.1	ran-binding protein 3-like isoform 4
NM_001323275.2	NP_001310204.1	ran-binding protein 3-like isoform 5
NM_001323276.2	NP_001310205.1	ran-binding protein 3-like isoform 6
NM_001323277.2	NP_001310206.1	ran-binding protein 3-like isoform 7
NM_001323278.2	NP_001310207.1	ran-binding protein 3-like isoform 8
NM_001323279.2	NP_001310208.1	ran-binding protein 3-like isoform 9
NM_001323280.2	NP_001310209.1	ran-binding protein 3-like isoform 10
NM_145000.5	NP_659437.3	ran-binding protein 3-like isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables SMAD binding	IPI IPI: Inferred from physical interaction	25755279	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RANBP3L Protein Structure

Ran_BP1

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

ran-binding protein 3-like

RANBP3L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RANBP3L	Q86VV4	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	RANBP3L	Q86VV4	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	RANBP3L	Q86VV4	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	RANBP3L	Q86VV4	KIF24	Homo sapiens	Q5T7B8-2	Y2H Prey Pooling	32296183
Intra	RANBP3L	Q86VV4	KIF24	Homo sapiens	Q5T7B8-2	Y2H Array	32296183
Intra	RANBP3L	Q86VV4	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	RANBP3L	Q86VV4	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	RANBP3L	Q86VV4	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	RANBP3L	Q86VV4	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	RANBP3L	Q86VV4	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RANBP3L	Q86VV4	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RANBP3L	Q86VV4	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183
Intra	RANBP3L	Q86VV4	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11647	RANBP3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RANBP3L	MGD	MGI:2444654
Felis catus	RANBP3L	VGNC	VGNC:64489
Macaca mulatta	RANBP3L	VGNC	VGNC:110438
Rattus norvegicus	RANBP3L	RGD	RGD:1307559
Bos taurus	RANBP3L	VGNC	VGNC:33711

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