2. Gene
  3. TRIP6 - thyroid hormone receptor interactor 6 Gene

TRIP6 - thyroid hormone receptor interactor 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2

Gene ID: 7205 | Gene type: protein coding

About TRIP6

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,867,387-100,873,454 (from NCBI)

This gene has 9 transcripts (splice variants), 107 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 26.6), kidney (RPKM 24.0) and 25 other tissues.

Summary

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

TRIP6 Products(1)

mRNA Protein Name
NM_003302.3 NP_003293.2 thyroid receptor-interacting protein 6
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables interleukin-1 receptor binding IDA
IDA: Inferred from direct assay
15657077 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
15657077 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10826496 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
14688263 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15657077 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoskeleton IDA
IDA: Inferred from direct assay
16624523 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
14688263 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10826496 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIP6 Protein Structure

LIM

LIM: LIM domain (279 - 334)

LIM

LIM: LIM domain (339 - 395)

LIM

LIM: LIM domain (399 - 461)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

thyroid receptor-interacting protein 6

OPA-interacting protein 1

TRIP6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRIP6 Q15654 ZBP1 Homo sapiens A2RRL9
Y2H Array
25416956
Intra
TRIP6 Q15654 ZBP1 Homo sapiens A2RRL9
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
25416956
Intra
TRIP6 Q15654 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
25416956
Intra
TRIP6 Q15654 CEP57L1 Homo sapiens Q8IYX8-2
Validated Y2H
25416956
Intra
TRIP6 Q15654 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Array
25416956
Intra
TRIP6 Q15654 TPM3 Homo sapiens Q5VU62
Y2H Array
25416956
Intra
TRIP6 Q15654 TPM3 Homo sapiens Q5VU62
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 CTAG2 Homo sapiens O75638
Y2H Array
31515488
Intra
TRIP6 Q15654 CTAG2 Homo sapiens O75638
Y2H Array
25416956
Intra
TRIP6 Q15654 CTAG2 Homo sapiens O75638
Validated Y2H
25416956
Intra
TRIP6 Q15654 CREB5 Homo sapiens Q02930-3
Validated Y2H
25416956
Intra
TRIP6 Q15654 SLC15A3 Homo sapiens Q05CH4
Y2H Array
25416956
Intra
TRIP6 Q15654 WT1-AS Homo sapiens Q06250
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 WT1-AS Homo sapiens Q06250
Validated Y2H
25416956
Intra
TRIP6 Q15654 TMSB4X Homo sapiens Q0P5Q0
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 TMSB4X Homo sapiens Q0P5Q0
Validated Y2H
25416956
Intra
TRIP6 Q15654 HYKK Homo sapiens A0A0C4DGM4
Validated Y2H
25416956
Intra
TRIP6 Q15654 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra
TRIP6 Q15654 POM121L1P Homo sapiens Q3SYA9
Validated Y2H
25416956
Intra
TRIP6 Q15654 POM121L1P Homo sapiens Q3SYA9
Y2H Array
25416956
Intra
TRIP6 Q15654 POM121L1P Homo sapiens Q3SYA9
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 yt011_human Homo sapiens Q5W150
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 RNF213 Homo sapiens Q63HN8-6
Y2H Array
25416956
Intra
TRIP6 Q15654 VASN Homo sapiens Q6EMK4
Validated Y2H
32296183
Intra
TRIP6 Q15654 NR1D2 Homo sapiens Q6NSM0
Validated Y2H
32296183
Intra
TRIP6 Q15654 XRCC6BP1 Homo sapiens Q8N4L5
Validated Y2H
25416956
Intra
TRIP6 Q15654 NEU4 Homo sapiens Q8WWR8-2
Y2H Array
25416956
Intra
TRIP6 Q15654 NEU4 Homo sapiens Q8WWR8-2
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 NEU4 Homo sapiens Q8WWR8-2
Validated Y2H
25416956
Intra
TRIP6 Q15654 KIR2DL4 Homo sapiens Q99706
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 KIR2DL4 Homo sapiens Q99706
Validated Y2H
25416956
Intra
TRIP6 Q15654 KIR2DL4 Homo sapiens Q99706
Y2H Array
25416956
Intra
TRIP6 Q15654 OTUB2 Homo sapiens Q9BWI9
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 OTUB2 Homo sapiens Q9BWI9
Validated Y2H
25416956
Intra
TRIP6 Q15654 OTUB2 Homo sapiens Q9BWI9
Y2H Array
25416956
Intra
TRIP6 Q15654 HEL-S-42 Homo sapiens V9HWD0
Y2H Array
25416956
Intra
TRIP6 Q15654 HEL-S-42 Homo sapiens V9HWD0
Validated Y2H
25416956
Intra
TRIP6 Q15654 SNAI1 Homo sapiens O95863
Y2H Array
31515488
Intra
TRIP6 Q15654 CNTF Homo sapiens P26441
Y2H Array
25416956
Intra
TRIP6 Q15654 IP6K3 Homo sapiens Q96PC2
Validated Y2H
32296183
Intra
TRIP6 Q15654 PATZ1 Homo sapiens Q9HBE1-4
Validated Y2H
32296183
Intra
TRIP6 Q15654 MEMO1 Homo sapiens Q9Y316
Validated Y2H
25416956
Intra
TRIP6 Q15654 MEMO1 Homo sapiens Q9Y316
Y2H Array
25416956
Intra
TRIP6 Q15654 MEMO1 Homo sapiens Q9Y316
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 CCDC24 Homo sapiens Q8N4L8
Validated Y2H
32296183
Intra
TRIP6 Q15654 FOXD4L1 Homo sapiens Q9NU39
Validated Y2H
32296183
Intra
TRIP6 Q15654 PRKAA1 Homo sapiens Q13131
Y2H Array
25416956
Intra
TRIP6 Q15654 POM121 Homo sapiens Q96HA1-2
Validated Y2H
32296183
Intra
TRIP6 Q15654 ZIC1 Homo sapiens Q15915
Validated Y2H
32296183
Intra
TRIP6 Q15654 GNE Homo sapiens Q9Y223-2
Validated Y2H
32296183
Intra
TRIP6 Q15654 PLEKHN1 Homo sapiens Q494U1-3
Validated Y2H
32296183
Intra
TRIP6 Q15654 RANBP3L Homo sapiens Q86VV4
Validated Y2H
32296183
Intra
TRIP6 Q15654 NSMF Homo sapiens Q6X4W1-2
Validated Y2H
32296183
Intra
TRIP6 Q15654 SHISA6 Homo sapiens Q6ZSJ9
Validated Y2H
32296183
Intra
TRIP6 Q15654 GLIS3 Homo sapiens Q8NEA6-2
Validated Y2H
32296183
Intra
TRIP6 Q15654 PTPN14 Homo sapiens Q15678
Validated Y2H
32296183
Intra
TRIP6 Q15654 PRKAA2 Homo sapiens P54646
Validated Y2H
25416956
Intra
TRIP6 Q15654 PRKAA2 Homo sapiens P54646
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra
TRIP6 Q15654 SIK3 Homo sapiens Q9Y2K2-7
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 SIK3 Homo sapiens Q9Y2K2-7
Y2H Array
25416956
Intra
TRIP6 Q15654 NEDD9 Homo sapiens Q14511
Validated Y2H
25416956
Intra
TRIP6 Q15654 TIE1 Homo sapiens P35590
Validated Y2H
32296183
Intra
TRIP6 Q15654 MISP Homo sapiens Q8IVT2
Validated Y2H
32296183
Intra
TRIP6 Q15654 MIIP Homo sapiens Q5JXC2
Validated Y2H
32296183
Intra
TRIP6 Q15654 FAM222B Homo sapiens Q8WU58
Validated Y2H
32296183
Intra
TRIP6 Q15654 TXNDC5 Homo sapiens Q86UY0
Validated Y2H
25416956
Intra
TRIP6 Q15654 TXNDC5 Homo sapiens Q86UY0
Y2H Array
25416956
Intra
TRIP6 Q15654 SMG9 Homo sapiens Q9H0W8
Validated Y2H
32296183
Intra
TRIP6 Q15654 PIGS Homo sapiens Q96S52
Validated Y2H
32296183
Intra
TRIP6 Q15654 TXN2 Homo sapiens Q99757
Y2H Array
25416956
Intra
TRIP6 Q15654 TXN2 Homo sapiens Q99757
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 GNAI2 Homo sapiens P04899
Y2H Array
25416956
Intra
TRIP6 Q15654 GNAI2 Homo sapiens P04899
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 ATP5PO Homo sapiens P48047
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 ATP5PO Homo sapiens P48047
Y2H Array
25416956
Intra
TRIP6 Q15654 SLC25A6 Homo sapiens P12236
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 SLC25A6 Homo sapiens P12236
Validated Y2H
25416956
Intra
TRIP6 Q15654 SLC25A6 Homo sapiens P12236
Y2H Array
25416956
Intra
TRIP6 Q15654 GSE1 Homo sapiens Q14687
Validated Y2H
25416956
Intra
TRIP6 Q15654 GSE1 Homo sapiens Q14687
Y2H Array
25416956
Intra
TRIP6 Q15654 GSE1 Homo sapiens Q14687
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 GSE1 Homo sapiens Q14687
Y2H Array
29892012
Intra
TRIP6 Q15654 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra
TRIP6 Q15654 ZNF541 Homo sapiens Q9H0D2
Validated Y2H
32296183
Cross
TRIP6 Q15654 Hoxa1 Mus musculus P09022
BiFC
23088713
Intra
TRIP6 Q15654 SAXO1 Homo sapiens Q8IYX7
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 SAXO1 Homo sapiens Q8IYX7
Validated Y2H
25416956
Intra
TRIP6 Q15654 SAXO1 Homo sapiens Q8IYX7
Y2H Array
25416956
Intra
TRIP6 Q15654 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
25416956
Intra
TRIP6 Q15654 KCTD9 Homo sapiens Q7L273
Validated Y2H
32296183
Intra
TRIP6 Q15654 RHOA Homo sapiens P61586
Y2H Array
25416956
Intra
TRIP6 Q15654 RHOA Homo sapiens P61586
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 OIP5 Homo sapiens O43482
Y2H Array
31515488
Intra
TRIP6 Q15654 MIEN1 Homo sapiens Q9BRT3
Validated Y2H
32296183
Intra
TRIP6 Q15654 PDGFRB Homo sapiens P09619
Y2H Array
25416956
Intra
TRIP6 Q15654 INCA1 Homo sapiens Q0VD86
Y2H Array
25416956
Intra
TRIP6 Q15654 C11orf87 Homo sapiens Q6NUJ2
Validated Y2H
32296183
Intra
TRIP6 Q15654 TRIM29 Homo sapiens Q14134
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 PPP1R16A Homo sapiens Q96I34
Y2H Array
19060904
Intra
TRIP6 Q15654 PPP1R16A Homo sapiens Q96I34
Y2H Pooling
19060904
Intra
TRIP6 Q15654 PPP1R16A Homo sapiens Q96I34
Y2H Pooling
16189514
Intra
TRIP6 Q15654 NCK2 Homo sapiens O43639
Y2H Pooling
16189514
Intra
TRIP6 Q15654 NCK2 Homo sapiens O43639
Y2H Array
31515488
Intra
TRIP6 Q15654 NCK2 Homo sapiens O43639
Validated Y2H
25416956
Intra
TRIP6 Q15654 NCK2 Homo sapiens O43639
Y2H Array
25416956
Intra
TRIP6 Q15654 PIN1 Homo sapiens Q13526
Validated Y2H
25416956
Intra
TRIP6 Q15654 FRS3 Homo sapiens O43559
Validated Y2H
25416956
Intra
TRIP6 Q15654 FRS3 Homo sapiens O43559
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 LMO2 Homo sapiens P25791
Validated Y2H
25416956
Intra
TRIP6 Q15654 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
TRIP6 Q15654 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TRIP6 Q15654 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 RFX3 Homo sapiens P48380
Validated Y2H
25416956
Intra
TRIP6 Q15654 ABI2 Homo sapiens Q9NYB9
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 ABI2 Homo sapiens Q9NYB9
Validated Y2H
25416956
Intra
TRIP6 Q15654 ABI2 Homo sapiens Q9NYB9
Y2H Array
25416956
Intra
TRIP6 Q15654 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra
TRIP6 Q15654 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
Intra
TRIP6 Q15654 CATSPER1 Homo sapiens Q8NEC5
Y2H Pooling
16189514
Intra
TRIP6 Q15654 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
TRIP6 Q15654 TRAF3IP2 Homo sapiens O43734
Validated Y2H
25416956
Intra
TRIP6 Q15654 TRAF3IP2 Homo sapiens O43734
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 BEX2 Homo sapiens Q9BXY8
Validated Y2H
32296183
Intra
TRIP6 Q15654 AQP1 Homo sapiens P29972
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 AQP1 Homo sapiens P29972
Y2H Array
25416956
Intra
TRIP6 Q15654 HOXB9 Homo sapiens P17482
Validated Y2H
25416956
Intra
TRIP6 Q15654 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32296183
Intra
TRIP6 Q15654 ZNF580 Homo sapiens Q9UK33
Validated Y2H
32296183
Intra
TRIP6 Q15654 RAD23A Homo sapiens P54725
Y2H Array
25416956
Intra
TRIP6 Q15654 STK16 Homo sapiens O75716
Validated Y2H
25416956
Intra
TRIP6 Q15654 STK16 Homo sapiens O75716
Y2H Array
25416956
Intra
TRIP6 Q15654 EXOC3-AS1 Homo sapiens Q8N2X6
Y2H Pooling
16189514
Intra
TRIP6 Q15654 EXOC3-AS1 Homo sapiens Q8N2X6
Validated Y2H
25416956
Intra
TRIP6 Q15654 METTL17 Homo sapiens Q9H7H0
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 METTL17 Homo sapiens Q9H7H0
Validated Y2H
25416956
Intra
TRIP6 Q15654 METTL17 Homo sapiens Q9H7H0
Y2H
21516116
Intra
TRIP6 Q15654 METTL17 Homo sapiens Q9H7H0
Y2H Array
25416956
Intra
TRIP6 Q15654 METTL17 Homo sapiens Q9H7H0
Y2H Array
29892012
Intra
TRIP6 Q15654 TCAF1 Homo sapiens Q9Y4C2
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 TCAF1 Homo sapiens Q9Y4C2
Y2H Array
25416956
Intra
TRIP6 Q15654 TEKT4 Homo sapiens Q8WW24
Y2H Array
31515488
Intra
TRIP6 Q15654 TEKT4 Homo sapiens Q8WW24
Validated Y2H
25416956
Intra
TRIP6 Q15654 TEKT4 Homo sapiens Q8WW24
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 TTLL10 Homo sapiens Q6ZVT0
Y2H Array
25416956
Intra
TRIP6 Q15654 MSRB3 Homo sapiens Q8IXL7
Validated Y2H
25416956
Intra
TRIP6 Q15654 KLK15 Homo sapiens Q9H2R5
Validated Y2H
25416956
Intra
TRIP6 Q15654 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
Intra
TRIP6 Q15654 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Intra
TRIP6 Q15654 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
TRIP6 Q15654 EPDR1 Homo sapiens Q9UM22
Validated Y2H
32296183
Intra
TRIP6 Q15654 MAPKBP1 Homo sapiens O60336
Y2H Prey Pooling
25416956
Intra
TRIP6 Q15654 MAPKBP1 Homo sapiens O60336
Y2H Array
25416956
Intra
TRIP6 Q15654 DMRT3 Homo sapiens Q9NQL9
Y2H Array
25416956
Intra
TRIP6 Q15654 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
25416956
Cross
TRIP6 Q15654 SVIL Bos taurus O46385
Y2H
16880273
Cross
TRIP6 Q15654 SVIL Bos taurus O46385
Pull Down
16880273
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lipomatosis, Multiple

Lipoma

Familial Multiple Lipomatosis

Lipomatosis, Familial Multiple

Benign Lipomatous Tumor

Lipomatous Neoplasm

Multiple Lipomatosis

Fml

Lipo

Benign Tumor Of Adipose Tissue

Lipomatous Tumor

Tumor Of Adipose Tissue

Neoplasms, Adipose Tissue

Lipomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15081 TRIP6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRIP6 VGNC VGNC:80699
Mus musculus TRIP6 MGD MGI:1343458
Rattus norvegicus TRIP6 RGD RGD:1583180
Canis familiaris TRIP6 VGNC VGNC:54081
Bos taurus TRIP6 VGNC VGNC:107000
Macaca mulatta TRIP6 VGNC VGNC:81782