1. Gene
  2. Msr1 - macrophage scavenger receptor 1 Gene

Msr1 - macrophage scavenger receptor 1 Gene

Mus musculus

Also known as MSR; SR-A; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1

Gene ID: 20288 | Gene type: protein coding

About Msr1

Summary

Enables amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including endocytosis; positive regulation of Cholesterol storage; and positive regulation of macrophage derived foam cell differentiation. Acts upstream of or within lipoprotein transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; limb; neural tube; reproductive system; and yolk sac. Human ortholog(s) of this gene implicated in Barrett's esophagus; arteriosclerosis; and prostate Cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Msr1 Products(2)

mRNA Protein Name
NM_001113326.2 NP_001106797.2 macrophage scavenger receptor types I and II isoform b
NM_031195.3 NP_112472.3 macrophage scavenger receptor types I and II isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables amyloid-beta binding IGI
IGI: Inferred from genetic interaction
11240025 MGI
enables cargo receptor activity IGI
IGI: Inferred from genetic interaction
22438044 MGI
enables low-density lipoprotein particle binding IMP
IMP: Inferred from mutant phenotype
12376530 MGI
Biological Process GO Annotation Evidence Reference Source
involved in amyloid-beta clearance IGI
IGI: Inferred from genetic interaction
22438044 MGI
involved in amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
11240025 MGI
involved in cholesterol transport IMP
IMP: Inferred from mutant phenotype
12376530 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
17148552 MGI
acts upstream of or within lipoprotein transport IMP
IMP: Inferred from mutant phenotype
17148552 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11240025 MGI
involved in phagocytosis, engulfment IGI
IGI: Inferred from genetic interaction
22438044 MGI
involved in plasma lipoprotein particle clearance IMP
IMP: Inferred from mutant phenotype
12376530 MGI
involved in positive regulation of cholesterol storage IMP
IMP: Inferred from mutant phenotype
12376530 MGI
involved in positive regulation of macrophage derived foam cell differentiation IGI
IGI: Inferred from genetic interaction
12376530 MGI
involved in receptor-mediated endocytosis IGI
IGI: Inferred from genetic interaction
22438044 MGI
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
11240025 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage scavenger receptor types I and II

macrophage acetylated LDL receptor I and II

scavenger receptor type A

Recombinant Msr1 Proteins

Cat. No. Product Name Accession Purity
HY-P76782 CD204/MSR1 Protein, Mouse (HEK293, His) AAH03814.1 (W83-V354) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Msr1 NCBI NCBI:4481
Rattus norvegicus Msr1 NCBI NCBI:498638