CD204/MSR1 Protein, Mouse (HEK293, His)

CD204/MSR1 Protein, a membrane glycoprotein, crucially contributes to cholesterol accumulation in arterial walls during atherogenesis. With two receptor subunits, it facilitates endocytosis of various macromolecules, including modified low-density lipoproteins (LDL). As a homotrimer, CD204/MSR1 engages in key interactions, including its association with MYO18A, highlighting its functional role in cellular processes. CD204/MSR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD204/MSR1 protein, expressed by HEK293 , with N-His labeled tag.

CD204/MSR1 Protein, a membrane glycoprotein, plays a crucial role in the pathological accumulation of cholesterol in arterial walls during atherogenesis. Comprising two types of receptor subunits, this protein facilitates the endocytosis of a diverse array of macromolecules, including modified low-density lipoproteins (LDL). As a homotrimer, CD204/MSR1 engages in key interactions, such as its association with MYO18A, contributing to its functional role in cellular processes.

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse CD204 at 5 µg/mL (100 µL/well) can bind biotinylated advanced glycation endproducts of bovine serum albumin (AGE-BSA). The ED₅₀ for this effect is 92.81 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse CD204 at 5 µg/mL (100 µL/well) can bind biotinylated advanced glycation endproducts of bovine serum albumin (AGE-BSA) .The ED₅₀ for this effect is 92.81 ng/mL

Mouse

HEK293

N-His

AAH03814.1 (W83-V354)

20288  [NCBI]

WEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSRSV

Approximately 42-75 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.