Sfrp2 - secreted frizzled-related protein 2 Gene

Mus musculus

Also known as Sdf5

Gene ID: 20319 | Gene type: protein coding

About Sfrp2

Summary

Enables Wnt-protein binding activity; endopeptidase activator activity; and receptor ligand activity. Involved in several processes, including regulation of gene expression; regulation of protein phosphorylation; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; negative regulation of signal transduction; and regulation of endopeptidase activity. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; eye; and genitourinary system. Orthologous to human SFRP2 (secreted Frizzled related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp2 Products(1)

mRNA	Protein	Name
NM_009144.2	NP_033170.1	secreted frizzled-related protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	17462603	MGI
enables endopeptidase activator activity	IDA IDA: Inferred from direct assay	19079247	MGI
enables enzyme activator activity	IDA IDA: Inferred from direct assay	19079247	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9096311	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	20723538	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	19850029	MGI
acts upstream of or within Wnt signaling pathway involved in somitogenesis	IGI IGI: Inferred from genetic interaction	18257070	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	16467359	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	18729207	MGI
involved in branching involved in blood vessel morphogenesis	IDA IDA: Inferred from direct assay	19458075	MGI
acts upstream of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18257070	MGI
acts upstream of cardiac muscle cell apoptotic process	IDA IDA: Inferred from direct assay	17251350	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	18729207	MGI
involved in cellular response to X-ray	IDA IDA: Inferred from direct assay	19778523	MGI
acts upstream of or within chondrocyte development	IMP IMP: Inferred from mutant phenotype	18729207	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	19079247	MGI
acts upstream of or within convergent extension involved in axis elongation	IGI IGI: Inferred from genetic interaction	18257070	MGI
acts upstream of or within development of primary male sexual characteristics	IGI IGI: Inferred from genetic interaction	19100252	MGI
acts upstream of or within digestive tract morphogenesis	IGI IGI: Inferred from genetic interaction	19300477	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	18729207	MGI
involved in hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	19778523	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	19100252	MGI
acts upstream of mesodermal cell fate specification	IGI IGI: Inferred from genetic interaction	17462603	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	19850029	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	19850029	MGI
acts upstream of or within negative regulation of JUN kinase activity	IGI IGI: Inferred from genetic interaction	19300477	MGI
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	10654605	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17804636	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	17462603	MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process	IDA IDA: Inferred from direct assay	17251350	MGI
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	10980594	MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	17251350	MGI
involved in negative regulation of dermatome development	IDA IDA: Inferred from direct assay	10654605	MGI
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	9391078	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	10980594	MGI
acts upstream of or within negative regulation of mesodermal cell fate specification	IGI IGI: Inferred from genetic interaction	17462603	MGI
involved in negative regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10980594	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	19850029	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	19850029	MGI
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	19458075	MGI
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19001373	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18166153	MGI
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	10980594	MGI
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10980594	MGI
acts upstream of or within positive regulation of endopeptidase activity	IDA IDA: Inferred from direct assay	19079247	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	18166153	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20723538	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20723538	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	18729207	MGI
involved in regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	9391078	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18729207	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18729207	MGI
acts upstream of or within regulation of establishment of planar polarity	IGI IGI: Inferred from genetic interaction	19300477	MGI
involved in regulation of midbrain dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	22290867	MGI
involved in regulation of neuron projection development	IDA IDA: Inferred from direct assay	22290867	MGI
involved in regulation of stem cell division	IDA IDA: Inferred from direct assay	19778523	MGI
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	19778523	MGI
involved in sclerotome development	IEP IEP: Inferred from expression pattern	10654605	MGI
acts upstream of or within somitogenesis	IGI IGI: Inferred from genetic interaction	16467359	MGI
acts upstream of stem cell fate specification	IGI IGI: Inferred from genetic interaction	17462603	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	9391078	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

secreted frizzled-related protein 2

SARP-1	sFRP-2
secreted apoptosis-related protein 1	secreted frizzled-related sequence protein 2
secreted frizzled-related sequence protein 5	stromal cell derived factor 5

Recombinant Sfrp2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74553	SFRP2 Protein, Mouse (HEK293, His)	NP_033170.1 (L25-C295)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12775	SFRP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sfrp2	NCBI	NCBI:6423
Macaca fascicularis	Sfrp2	NCBI	NCBI:102147309

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